(3-ammonio-4-methoxyphenyl)(2-hydroxyethyl)ammonium sulphate

Hydrolysis

Description of key information

The test item was determined to be unstable in sterile aqueous solutions buffered at pH levels of 4, 7, and 9 after incubation for 5 days at 50 ± 0.5 °C. The test substance had fully degraded by Day 5 at pH 4, and had a half-life of 1.1 and 4.3 days at pH 7 and 9, respectively.

Key value for chemical safety assessment

Half-life for hydrolysis:

1.1 d

at the temperature of:

50 °C

Additional information

The test item was tested for hydrolysis according to the OECD Guideline 111 and GLP. The hydrolysis of the test item was studies after 5 days at 50°C and pH 4, 7 and 9.

After five days, at pH 4 the measured concentrations were < LOQ and so the percentage recovery cannot be calculated.

After five days, the percent of initial sample recovered in the pH 7 samples was 3.8 and 4.8%, respectively. After five days, the percent of initial sample recovered in the pH 9 samples was 46.8 and 42.3%, respectively.

The test item was determined to be unstable in sterile aqueous solutions buffered at pH levels of 4, 7, and 9 after incubation for 5 days at 50 ± 0.5 °C. The test substance was fully degraded by Day 5 at pH 4, and had a half-life of 1.1 and 4.3 days at pH 7 and 9, respectively.

This study satisfies the guideline requirements of the preliminary study of the OECD guideline 111.