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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

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Description of key information

Inhalable fraction

Additional information

Granulometry is of considerable importance for the toxic properties of a substance as it influences aspects such as the route of exposure of humans and toxicity by inhalation; the choice of route of administration for animal testing; the efficiency of uptake in an organism and the distribution in the environment.

For this purpose fractions can be divided in:

Inhalable fraction(the mass fraction of particles that can be inhaled by nose and mouth. Particles >100 μm are not included in the inhalable convention;

Thoracic fraction(the mass fraction of the inhaled particles that passes the larynx). The convention for thoracic fraction sets that 50% of the particles in air with an aerodynamic diameter of 10 μm belong to the thoracic fraction;

Respirable fraction(the mass fraction of the inhaled particles that reaches the alveoli) The convention for respirable fraction sets that 50% of particles with an aerodynamic diameter of 4 μm belong to the respirable fraction.


The tested substance presented a granulometry of 17.533 µm (D50 after 2 minutes of ultrasonic treatement) that can be considered as inhalable