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EC number: 947-136-5
CAS number: -
The test substance was tested for
mutagenic effects in vitro in histidine-requiring strains of Salmonella
typhimurium, according to the OECD Guideline 471 (1983).
The following strains of Salmonella
typhimurium were used: TA 98, TA 100, TA 1535 and TA 1537. The test was
performed with and without the addition of rat-liver post mitochondrial
supernatant (S9 fraction) as an extrinsic metabolic activation system.
The compound was dissolved in DMSO and tested at five concentrations in
the range of 61.7 to 5000.0 µg/plate in the presence
and absence of a metabolic activation system. In order to confirm the
results, the experiments were repeated with and without metabolic
activation at the same concentrations. Each strain was additionally
tested in the presence and in the absence of a metabolic activation
system with a suitable, known mutagen as positive control.
The original experiment with and without
metabolic activation and the confirmatory experiment without activation
were performed as standard plate incorporation assay. The confirmatory
experiment with metabolic activation was carried out as preincubation
In both experiments, performed with and
without metabolic activation, none of the tested concentrations of the
test substance led to an increase in the incidence of
histidine-prototrophic mutants by comparison with the negative control.
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