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EC number: 306-115-5
CAS number: 96152-43-1
There is not enough available data for this endpoint for CAS:
96152-43-1, therefore studies from supporting, structurally similar
substances have been used as for read-across purposes to address some
In vitro studies
Ames test - In this key study for in vitro genetic toxicity
(Dakoulas, 2010) the study was conducted according to OECD Guideline 471
(Bacterial Reverse Mutation Assay) and GLP. A reliability rating of 1
was assigned according to the criteria of Klimisch, 1997.
Mouse lymphoma - In this key study for in vitro genetic toxicity
(Wininger et al, 1985, report number: SOCAL 2322) there was no
guideline specified, however it was considered to be comparable to OECD
Guideline 476 (In vitro Mammalian Cell Gene Mutation Test). The study
was conducted in line with GLP. The reliability rating for this study is
1, however this is being used as read across as there was not enough
available data to fulfil this endpoint for the test material and so the
reliability rating will be reduced to 2, according to the criteria of
In vivo study
In the key study for in vivo genetic toxicity (Ivett, 1997, Corning
Hazleton report number: 17865-0-455CO) the study was conducted according
to OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test). The
study was conducted in line with GLP. The reliability rating for this
study is 1, however this is being used as read across from a supporting
substance (Phenol, tetrapropenyl-, sulfurized, calcium salts CAS No.
68855-45-8) as there was no available data to fulfil this endpoint for
the test material and so the reliability rating will be reduced to 2,
according to the criteria of Klimisch, 1997.
The results for the key parameters chosen for genetic toxicity were
negative and so the criteria set out in Directive 67/548/EEC and also
Regulation (EC) no 1272/2008 do not apply, therefore classification for
genetic toxicity was not considered to be necessary.
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