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EC number: 306-115-5
CAS number: 96152-43-1
There were no deaths during the study.
The left (control) eyes were free of evidence of ocular irritation and
other findings for the duration of the study.
There were no remarkable body weight changes noted during the study.
In an eye irritation study conducted to OED method 405 in compliance
with GLP, the primary ocular irritation potential of the test material
was evaluated with New Zealand White rabbits.
There was one group of six albino rabbits that received a single,
unwashed exposure. Each 0.1-m1 dose of the test article was instilled
into the lower conjunctival sac of the right eye. The eyelid was held
closed for approximately one second and released. The left eye was
manipulated in a similar manner as the right eye and served as a
The eyes were examined for ocular reactions in accordance with the
method of Draize at approximately one, 24, 48 and 72 hours after dosing
and on days 4 and 7 if irritation persisted. Sodium fluorescein was used
to aid in revealing possible corneal damage at 72 hours and on day 7.
Conjunctival irritation, including positive irritation (grade 2) for
four rabbits, was noted for all animals. There were no iridal or corneal
findings in the treated eyes. All conjunctival irritation completely
subsided by day 7.
The Maximum Average Score for the test material was 5.3 at one-hour
The mean value of the scores for cornea opacity, iris lesions, redness &
oedema of the conjuctivae, for 24, 48 and 72 hours was calculated and
was considered to be non-irritating in accordance with the CLP
Regulation EC 1272/2008, and also Directive 67/548/EEC (Dangerous
The study is being used as read across from a structurally similar
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