Registration Dossier

Diss Factsheets

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

Additional information

Category approach and physicochemical endpoints

The substance being Registered in this particular dossier is one of a series of chemically similar materials each of which is composed of a closely related series of alkylated phenol species. This set of materials and the relationships to the registration material are described in detail in Section 13. Although the alkylated phenol series present in the different substances are considered different enough to warrant separate registrations, they are none the less all extremely closely related and the EPIWIN program predicts very similar properties for a number of representative structures. This high degree of similarity is considered sufficient grounds to support the use of read across between the different members of these “phenate” substances for the studies conducted to examine their physicochemical properties. The similarity is further demonstrated by those endpoints where multiple data records exist for materials within the Category (including the Registration material).

The data indicate that the category members demonstrate a predictable similarity with minor changes to absolute values as one goes from lower molecular weight to higher molecular weight in the category.

Given these similarities and the support for the category demonstrated by the endpoint data, as well as further support coming from the toxicological and fate data, it is considered that the physicochemical data on the other substances within the category is applicable to be used for the substance being registered for the endpoints where specific data for the Registration material are not available.

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