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EC number: 306-115-5
CAS number: 96152-43-1
The octanol/water partition coefficient (log Kow) has been evaluated using the HPLC methods (OECD 117) for structurally similar substances
using a weight of evidence approach. Based on the results from these studies, the log Kow for the registration substance is considered likely to be in the range of 9.5-10.1. A value of 9.5 is adopted for purposes of further assessment.
There are no available data for this
endpoint for Registration material CAS: 96152-43-1, therefore studies
from supporting, structurally similar substances have been used as for
read-across purposes to address this endpoint. All materials within this
IUCLID5 category are believed to have a log Kow value > 6. Two robust
studies are available for similar materials within this category and
these have been used to create a range within which the log Kow is
believed to fall for this material. These two studies have been selected
as the most reliable indicators for this material as they were performed
following guideline methodology, unlike the other available information.
The following two key studies have been
used to fulfil this endpoint:
- Dutta, 2010/122384 -86 -5, conducted to
the OECD 117 method.
Result: Log Kow (weighted average) of 9.5
has been calculated
- Dutta, 2010/68855 -45 -8, conducted to
the OECD 117 method, Result: Log Kow (weighted average) of 10.1 has been
Supporting information is also available:
- The Rausina, 1996 study (CAS No.
122384-87-6/68784-26-9) was assigned a reliability rating
of 2 according to the criteria of Klimisch, 1997 as it is considered to
be a well-conducted non-guideline non-GLP study. Restricted because
study lacks detailed information on individual data and the study is a
specialized method that was developed due to very limited water
solubility and difficulty in analysis. Result: The log Kow was
determined by HPLC to be 6.6.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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