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EC number: 214-987-2
CAS number: 1241-94-7
The acute inhalation toxicity of
Santicizer 141 towards rats was investigated in a test similar to OECD
Guideline 403. Five male rats were exposed to Santicizer 141 at a
concentration of 2.1 mg/l for 6 hours. The procedure is designed to
provide a single inhalation exposure at an elevated temperature to a
concentrated atmosphere of the vaporized test material for potential
toxic effects. Signs of intoxication and mortality are observed during
the observation period of 10 days. All animals survived the 6 hour
exposure period; 3 of 5 test animals succumbed during 10 day observation
period. It was concluded that the vapors were harmful under conditions
of the test. The LC50 was calculated to be 2.1 mg/l (nominal
concentration) for 6 h exposure. Based on these results and according to
the EU criteria outlined in 67/548/EEC and 1272/2008/EC (CLP/EU-GHS)
Santicizer 141 needs to be classified as harmful by inhalation.
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