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EC number: 214-987-2 | CAS number: 1241-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
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- Flash point
- Auto flammability
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- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March, 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was not conducted according to an existing OECD guideline, and no data on GLP, but acceptable basic information.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In this Range Finding Acute Oral Toxicity study the acute oral toxic effects of Santicizer 141 was tested in Sprague Dawley strain albino male and female rats. The undiluted compound was fed by stomach tube at 6 doses (2000, 5010, 7940, 10000, 12600, and 15800 mg/kg). Number of animals were: 1 female at 2000, 5010, and 7940 mg/kg; 5 animals/sex at 10000, 12600, and 15800 mg/kg. Daily observations were made for 10 days for toxic symptoms and the viscera of the test animals were examined macroscopically.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl diphenyl phosphate
- EC Number:
- 214-987-2
- EC Name:
- 2-ethylhexyl diphenyl phosphate
- Cas Number:
- 1241-94-7
- Molecular formula:
- C20H27O4P
- IUPAC Name:
- 2-ethylhexyl diphenyl phosphate
- Details on test material:
- - Name of test material (as cited in study report): Santicizer 141
- Lot/batch No.: QK 735
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS: No data
ENVIRONMENTAL CONDITIONS: No data
IN-LIFE DATES: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- No data
- Doses:
- 2000, 5010, 7940, 10000, 12600, and 15800 mg/kg
- No. of animals per sex per dose:
- 2000, 5010, and 7940 mg/kg: 1 female; 10000, 12600, and 15800 mg/kg: 5 animals/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations and weighing: observation of toxic symptoms: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 15 800 mg/kg bw
- Mortality:
- 1 female died at dose 12600 and 15800 mg/kg. Survival time was 3 to 5 days.
- Clinical signs:
- other: Toxic symptoms included diarrhea for 1 day, reduced activity and appetite, and tremors and increasing weakness to near collapse lasting 5 to 7 days in animals of the last 3 groups.
- Gross pathology:
- At autopsy there were hemorrhagic areas of the liver, lungs, and kidneys, and intestinal inflammation. Surviving animals were sacrificed 10 days after dosing. Hemorrhagic areas of the lungs were observed in a few instances; otherwise the viscera appeared normal by macroscopic examination.
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 was found to be > 15800 mg/kg. Based on these results and according to the EU classification criteria outlined in 67/548/EEC and 1272/2008 the substance does not have to be classified.
- Executive summary:
In this Range Finding Acute Oral Toxicity study the acute oral toxic effects of Santicizer 141 was tested in Sprague Dawley strain albino male and female rats. The undiluted compound was fed by stomach tube at 6 doses (2000, 5010, 7940, 10000, 12600, and 15800 mg/kg). Number of animals were: 1 female at 2000, 5010, and 7940 mg/kg; 5 animals/sex at 10000, 12600, and 15800 mg/kg. Daily observations were made for 10 days for toxic symptoms and the viscera of the test animals were examined macroscopically. Toxic symptoms included diarrhea for 1 day, reduced activity and appetite, and tremors and increasing weakness to near collapse lasting 5 to 7 days in animals of the last 3 dose groups. One female died at dose 12600 and at 15800 mg/kg. Survival time was 3 to 5 days. At autopsy there were hemorrhagic areas of the liver, lungs, and kidneys, and intestinal inflammation. Surviving animals were sacrificed 10 days after dosing. Hemorrhagic areas of the lungs were observed in a few instances; otherwise the viscera appeared normal by macroscopic examination. The oral LD50 was thus found to be > 15800 mg/kg. Based on these results and according to the EU classification criteria outlined in 67/548/EEC and 1272/2008 the substance does not have to be classified.
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