2-ethylhexyl diphenyl phosphate

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

no data: aquatic toxicity unlikely

Marine water

Hazard assessment conclusion:

no data: aquatic toxicity unlikely

STP

Hazard assessment conclusion:

no hazard identified

Sediment (freshwater)

Hazard assessment conclusion:

no hazard identified

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

no hazard identified

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

no hazard identified

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

PNEC oral

PNEC value:

1.62 mg/kg food

Assessment factor:

90

Additional information

The log Koc value of 4.85 used in the calculation of soil and sediment PNEC's was calculated in EUSES 2.1 using the "predominantly hydrophobics"-(Q)SAR and an input value of 5.87 for log Kow.

Conclusion on classification

The acute and chronic aquatic toxicity of 2EHDPP has been tested with fish, invertebrates and algae. The assessment of the chronic aquatic toxicity of 2EHDPP is further supported by a high quality D. magna life cycle test that was conducted with a structurally analogous compound, isodecyl diphenyl phosphate (IDDPP, CAS RN 29761-21-5). The weight-of-evidence across all the studies is that no aquatic toxicity was found for 2EHDPP at or below the measured water solubility of 0.0506 mg/L at 21 deg.C.

 

PNEC FOR 2EHDPP 

Based on the weight-of-evidence analysis of the available aquatic toxicity dataset (see text above), 2EHDPP is not toxic to aquatic organisms at its water solubility. In addition, a high quality (Klimisch 1) chronic toxicity test with D. magna using a structurally analogous compound (IDDPP) was conducted and also found no toxicity at its water solubility. PNECaquatic cannot be developed using aquatic toxicity studies when no toxicity is found at or below the water solubility. Therefore, based on applicable guidance, the PNECaquatic for 2EHDPP is set at the water solubility of 0.0506 mg/L at 21 deg.C.

Based on the weight-of-evidence analysis of the available acute aquatic toxicity dataset (see text above), 2EHDPP is not acutely toxic to aquatic organisms at its water solubility (0.0506 mg/L at 21 deg.C). Therefore, based on applicable guidance, no acute classification of 2EHDPP is required.

Based on the weight-of-evidence analysis of the available chronic aquatic toxicity dataset, including data from a structural analog compound (isodecyl diphenyl phosphate, CAS RN 29761-21-5) with Daphnia magna (see text above), 2EHDPP is not chronically toxic to aquatic organisms at its water solubility of 0.0506 mg/L (25 deg.C).This is further supported by the facts that 2EHDPP is readily biodegradable and has a measured BCF of 934 L/kg. Therefore, based on applicable guidance, no chronic classification of 2EHDPP is required under either Directive 67/548/EEC or Regulation 1272/2008/EC.

Table 1. Properties and Degradation Data for 2EHDPP (S141, CAS RN 1241-94-7)
Endpoint	Results	Reference
Melting point	-30 deg.C	See CSR
Density	1.091 g/mL (25 deg.C)	See CSR
Aqueous solubility^1	0.0506 mg/L (21 deg.C)	David (2004)
LogKow^1	5.87 (25 deg.C)	Tunink (2009a)
Ready Biodegradation	Readily biodegradable OECD 301B – 75% Theoretical CO2 (ThCO2) evolution in 28 d, 10-d window met	Tunink (2009b)
Bioconcentration or Bioaccumulation Factors (BCFor BAF)	934±152 53 day uptake and depuration BCF with bluegill sunfish	Heidolph et al. (1982)
^1Measured using slow-stir methods (OECD Guidelines 105, 123)