Registration Dossier
Registration Dossier
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EC number: 214-987-2 | CAS number: 1241-94-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed similar to OECD guideline 405, not under GLP, but acceptable basic data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-ethylhexyl diphenyl phosphate
- EC Number:
- 214-987-2
- EC Name:
- 2-ethylhexyl diphenyl phosphate
- Cas Number:
- 1241-94-7
- Molecular formula:
- C20H27O4P
- IUPAC Name:
- 2-ethylhexyl diphenyl phosphate
- Details on test material:
- - Name of test material (as cited in study report): 2-ethylhexyl diphenyl phosphate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Concentration (if solution): 100% (undiluted) - Duration of treatment / exposure:
- No data
- Observation period (in vivo):
- No data
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SCORING SYSTEM: according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 hr
- Score:
- 10.6
- Reversibility:
- fully reversible within: 48 hr
- Remarks:
- results per animals not available
- Remarks on result:
- other: scoring method not specified
- Remarks:
- results per animals not available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hr
- Score:
- 2
- Reversibility:
- fully reversible within: 48 hr
- Remarks:
- results per animals not available
- Remarks on result:
- other: scoring method not specified
- Remarks:
- results per animals not available
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hr
- Score:
- 0
- Reversibility:
- other: not applicable
- Remarks:
- results per animals not available
- Remarks on result:
- other: scoring method not specified
- Remarks:
- results per animals not available
- Irritant / corrosive response data:
- It was noted that slight irritation of the rabbit eye was found. Given the report that only slight irritation was observed for both skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The reaction of the test material, 2-ethylhexyl diphenyl phosphate, on the rabbit eye was reported as slightly irritating. Given the report that only slight irritation was observed for both rabbit skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.
- Executive summary:
In a study, being conducted to a Draize design, test material, 2-ethylhexyl diphenyl phosphate, was applied undiluted to the eyes of three rabbits of unspecified strain. It was noted that slight irritation of the eye was found. Given the report that only slight irritation was observed for both rabbit skin and eye, it is considered that the irritant potential of 2-ethylhexyl diphenyl phosphate may be low and, therefore, in addition, it is considered unlikely that 2-ethylhexyl diphenyl phosphate possesses any corrosive properties.
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