Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 227-579-4 | CAS number: 5895-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
One GLP compliant dermal sensitsation study has been conductedc according to OECD Guideline 429 and EU B.42. It is considered to be reliable (1 on the Klimisch scale) and conducted according to GLP, with a minor exception. The substance has given a clear negative result in the local lymph node assay (LLNA) in mice. This study showed that the substance does not warrant classification as a skin sensitiser according to EU DSD and CLP schemes.
Migrated from Short description of key information:
A GLP-compliant local lymph node assay (LLNA) in the mouse has been conducted according to OECD guideline 429 and EU Method B.42. Three groups of four animals were treated with 50 µL (25 µl per ear) of the test material as a suspension in propylene glycol at concentrations of 25%, 10%, and 5% w/w. The test material was considered a non-sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No specific test data is available on respiratory sensitisation but experience in use suggests the substance in not a respiratory sensitiser.
Migrated from Short description of key information:
No specific test data is available on respiratory sensitisation but the substance has been used in industry for many years without any incidences of respiratory sensitisation.
Justification for classification or non-classification
The substance has given a clear negative result in the in vivo LLNA study. On this basis the substance is not classified as a skin sensitiser. No specific test data is available on respiratory sensitisation but experience in use suggests the substance is not a respiratory sensitiser and hence no classification is required. The available study data show that the substance is not a skin sensitiser and therefore does not trigger labelling as a skin sensitiser according to the criteria of the EU DSD and CLP schemes.
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