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EC number: -
CAS number: -
INDIVIDUAL AND MEAN SCORES OF CONJUNCTIVAE, IRIS AND CORNEA
TOTAL AND INDIVIDUAL SCORES OF OCULAR IRRITATION
Animal No: A0356
Animal No: A0374
Animal No: A0375
Acute eye irritation was assessed for „2-propanol and 2-butanol
production, distn. residue“ according to OECD guideline No 405. The test
item was instilled as supplied, into the eye of 3 New Zealand rabbits at
the dose of 0.1 mL. The experimental protocol was established on the
basis of the official method as defined in the OECD guideline No 405
dated April 24th, 2002 and the test method B.5 of the Council regulation
No 440/2008. The ocular reactions observed during the study have been
moderate to important and totally reversible in the three animals:
- at the conjunctivae level: a moderate redness noted 1 hour after
the test item instillation and totally reversible between days 7 and 9,
associated with a moderate to important chemosis noted 1 hour after the
test item instillation and totally reversible between days 7 and 8,
- at the iris level: a congestion, noted 1 hour after the test
item instillation in two animals, and totally reversible on day 1.
- at the corneal level: a moderate corneal opacity, noted 24 hours
after the test item instillation, and totally reversible on day 2.
In accordance with the Regulation EC No. 1272/2008 on
classification, labelling and packaging of substances and mixtures, the
test item has to be classified in category 2 “Irritating to eyes”. The
signal word “Warning” and hazard statement H319 “Causes serious eye
irritation” are required.
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