Dicalcium pyrophosphate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

9 - 12 February 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

GLP guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

2009

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187 Particle Size Analysis by Laser Diffraction

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Type of particle tested:

other: small particle size and stable larger agglomerates

Percentile:

D10

Mean:

1.5 µm

St. dev.:

0

Key result

Percentile:

D50

Mean:

12.5 µm

St. dev.:

0

Percentile:

D90

Mean:

31.5 µm

St. dev.:

0

Two test series of three measurements each were performed.

Test series	D10(µm)	D50(µm)	D90(µm)
1	1.5	12.7	31.6
2	1.5	12.5	31.4
Mean	1.5	12.6	31.5

The mass median aerodynamic diameter was calculated by using the results of the particle size distribution and the determination of the relative density by following equation:

 

              MMAD = D₅₀* (ρ/K)^0.5

with

              D₅₀ = volume median diameter (VMD) = 4.3 µm

              ρ = particle density =3.951 g/cm³

              K = shape factor (1 for spheric particles) = 1

Description of key information

Particle Size Distribution:

D50 = 12.6 µm (OECD 110, GLP)