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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
9 - 12 February 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
GLP guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Qualifier:
according to
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Version / remarks:
2009
Qualifier:
according to
Guideline:
other: CIPAC MT 187 Particle Size Analysis by Laser Diffraction
GLP compliance:
yes (incl. certificate)
Type of method:
Laser scattering/diffraction
Type of particle tested:
other: small particle size and stable larger agglomerates
Percentile:
D10
Mean:
1.5 µm
St. dev.:
0
Key result
Percentile:
D50
Mean:
12.5 µm
St. dev.:
0
Percentile:
D90
Mean:
31.5 µm
St. dev.:
0

Two test series of three measurements each were performed.

Test series

D10(µm)

D50(µm)

D90(µm)

1

1.5

12.7

31.6

2

1.5

12.5

31.4

Mean

1.5

12.6

31.5

The mass median aerodynamic diameter was calculated by using the results of the particle size distribution and the determination of the relative density by following equation:

 

              MMAD = D50* (ρ/K)0.5

with

              D50 = volume median diameter (VMD) = 4.3 µm

              ρ = particle density =3.951 g/cm³

              K = shape factor (1 for spheric particles) = 1

Description of key information

Particle Size Distribution:

D50 = 12.6 µm (OECD 110, GLP)

Additional information