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Long-term toxicity to fish

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Experimental data on the bioaccumulation potential of dicalcium pyrophosphate are not available. Read across data indicate that the substance is not acutely toxic to fish. Bioaccumulation of dicalcium pyrophosphate is not anticipated. When dissolved in water (and so animal tissues/fluids) it will dissociate to the ions "phosphate" and "calcium”. Both ions are ubiquitous in the environment and are essential micronutrients for many organisms. Calcium and phosphate are natural ionic components of blood, cell fluids, etc.. Calcium phosphate, in the form of hydroxyapatite, is an essential part of vertebrate bones. Phosphate is also needed for the synthesis of phospholipids, a major component of cell membranes. Thus, the uptake and concentration level of phosphate and calcium is strongly controlled and regulated by a number of mechanisms, whereby the metabolism of calcium and phosphate is interrelated. Excess calcium and phosphate is excreted. Long-term toxicity is thus considered unlikely.

A chronic toxicity of the substance is not anticipated due to the lack of acute toxicity and the fact that calcium and phosphate are essential micronutrients for fish.