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EC number: 232-221-5 | CAS number: 7790-76-3
Skin sensitisation: not sensitising (OECD 406 (GPMT), GLP)
Table 3: Individual animal weights (g) at start / test end (test group)
Body weight change
Individual weight of control group
Table 4: Individual animal weights (g) at test start and at test end (control group)
Table 5: Skin reactions of test animals after treatment with the test material
Numerical grading after
Table 6: Skin reactions of control animals after treatment with the test material
Table 7: Skin reactions of animals after challenge treatment with HCA 55 % in vaseline
The skin sensitising potential of dicalcium pyrophosphate was evaluated in a Guinea Pig Maximization Test (GPMT) conducted in accordance with OECD Guideline 406 and GLP. Preliminary tests were conducted to determine the test substance concentrations for intradermal and epicutaneous applications in the main study. Test animals (10 female Dunkin Hartley guinea pigs) were intradermally induced with the test substance as a 1% suspension in water (Day 0), and topically induced with the test substance at 100% moistened with water (Day 7) for 48 h. Control animals (5 females) were treated similarly with distilled water. Control and test animals were challenged by topical application of the test substance at 100% moistened in water (Day 21) for 24 h. For topical induction and challenge applications, the skin of the test animals was pre-treated with 10% sodium lauryl sulphate in vaseline for 24 h, respectively. Skin reactions were examined and evaluated 24 and 48 h after challenge patch removal (i.e. 48 and 72 h after challenge application). No skin reactions were noted at the challenge sites of the control and test animals at the observation time points. Hence, the test material did not induce any skin reactions in intradermally and topically induced guinea pigs after challenge treatment.
Therefore, the test material does not fulfil the criteria for classification according to Regulation (EC) No 1272/2008 (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), and is thus considered to be not skin sensitising.
The available data indicate that the substance does not meet the classification criteria in accordance with Regulation (EC) No 1272/2008 (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) for skin sensitisation.
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