Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-866-1 | CAS number: 75-37-6
Groups of male rats were exposed to the test substance by inhalation at starting concentrations of approximately 370, 470, 1500, and 2650 ppm in a closed, recirculating chamber. The duration of exposure was 4-5 hours. The chamber concentrations were monitored by gas chromatography every 10 minutes. Partition coefficients for the test substance between air and blood, liver, fat, and muscle were measured. The data for rate of chemical loss from the chamber and the partition coefficients were used with a physiologically-based pharmacokinetic model (PBPK) to estimate the kinetic constants for metabolism in the whole rat. Samples of urine were taken from the exposure chamber after the end of exposure an analyzed for metabolites by19F NMR.
The partition coefficients for the test substance were 1.69 for blood:air, 1.69 for liver:air, 5.63 for fat:air, and 1.47 for muscle:air. Analysis of the gas uptake data with a PBPK model showed that there was measurable metabolism of the test substance occurring in the rat. The estimated Vmax and Km were 7.8±0.9 mg/hr/kg and 27.9±3.7 mg/L, respectively. The best fit to the model was achieved by Michaelis-Menten kinetics. The concentration where metabolism was saturated was approximately 75000 ppm. 19F NMR showed fluoride ion and traces of an acyl fluoride in the urine. This indicates that the test substance was predominantly metabolized at the –CHF2carbon. The likely end-product of test substance metabolism was acetic acid. The results of this study show that the test substance is metabolized slowly in the rat, most likely through an oxidative route to acetic acid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again