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Registration Dossier
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EC number: 200-866-1 | CAS number: 75-37-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Anesthetic properties of a series of fluorinated compounds. I. Fluorinated hydrocarbons
- Author:
- Van Poznak A and Artusio JF Jr.
- Year:
- 1 960
- Bibliographic source:
- Toxicol. Appl. Pharmacol., 2:363-373
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report for SIAM 22, 1,1-Difluoroethane (HFC-152a), CAS No: 75-37-6
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- UNEP Publications
Materials and methods
- Type of study / information:
- Inhalation in humans.
- Endpoint addressed:
- acute toxicity: inhalation
- Principles of method if other than guideline:
- The test substance was inhaled briefly by several volunteers.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,1-difluoroethane
- EC Number:
- 200-866-1
- EC Name:
- 1,1-difluoroethane
- Cas Number:
- 75-37-6
- Molecular formula:
- C2H4F2
- IUPAC Name:
- 1,1-difluoroethane
Constituent 1
Results and discussion
- Results:
- The test substance was inhaled briefly by several volunteers at 50000 ppm, who noted good analgesia and impending loss of consciousness.
Applicant's summary and conclusion
- Executive summary:
The test substance was inhaled briefly by several volunteers at 50000 ppm, who noted good analgesia and impending loss of consciousness.
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