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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The test substance is a gas. Exposure by the oral route is not plausible. Testing by the oral route is not scientifically sound.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report Date:
1990

Materials and methods

Principles of method if other than guideline:
Male rats were administered a single dose by gavage and were observed for 14 days.
GLP compliance:
yes
Test type:
other: Approximate Lethal Dose (ALD)
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Purity: 99.9%

Test animals

Species:
rat
Strain:
other: Crl:CD®BR
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
200, 300, 450, 670, 1000, 1500 mg/kg
No. of animals per sex per dose:
1 male per dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: Approximate Lethal Dose (ALD)
Effect level:
> 1 500 mg/kg bw
Remarks on result:
other: Due to technical limitations, this was the maximum feasible dose tested

Applicant's summary and conclusion

Interpretation of results:
other: at worst slightly toxic
Remarks:
Criteria used for interpretation of results: expert judgment
Conclusions:
LD50 > 1500 mg/kg
Executive summary:

The test substance was administered as a single oral dose by intragastric intubation to male rats. No deaths occurred. Clinical signs of toxicity, including abdominal distension, lethargy, high carriage, wet and yellow-stained perineum, and/or diarrhoea were observed in non-lethally dosed animals. Under the conditions of this study, the ALD was >1500 mg/kg body weight. This material is considered at worst to be slightly toxic (ALD 500-5000 mg/kg) when administered as a single oral dose.