Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 200-866-1 | CAS number: 75-37-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because there is no emission to a sewage treatment plant
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
The substance is a gas, no emission to sewage tretment plant. - Endpoint:
- toxicity to microorganisms
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a study is available (Klimish score=4 because secondary source)
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached reporting format. - Analytical monitoring:
- yes
- Key result
- Duration:
- 6 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 472.57 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: Based on a read-across from an analogue from which EC50 > 730 mg/L.
- Conclusions:
- Based on the read-across approach from the analogue 1,1,1,2-tetrafluoroethane, the EC50 of 1,1-difluoroethane was determined to be > 472.57 mg/l based on growth inhibition.
- Executive summary:
A bacterial growth inhibition test was carried out with the analogue substance 1,1,1,2 -tetrafluoroethane on Pseudomonas putida.
HFC-134a showed a low toxicity towards P. putida. At the highest mean measured HFC-134a concentration of 730 mg/l no inhibition of the growth of P.putida was found during a period of 6 h and therefore, the EC50 based on growth inhibition was determined to be > 730 mg/l. On the basis of these results, the read-across approach was applied and the EC50 based on growth inhibition of 1,1 -difluoroethane was determined to be > 472.57 mg/l.
Referenceopen allclose all
Description of key information
Data waiving: In accordance with Column 2 adaptation statement of REACH Annex VIII the study does not need to be conducted if there as no emission to a sewage treatment plant.
Key value for chemical safety assessment
Additional information
Data waiving: In accordance with Column 2 adaptation statement of REACH Annex VIII the study does not need to be conducted if there as no emission to a sewage treatment plant.
Supporting study: A bacterial growth inhibition test was carried out with the analogue substance 1,1,1,2 -tetrafluoroethane on Pseudomonas putida. Based on the read-across approach from the analogue 1,1,1,2-tetrafluoroethane, the EC50 of 1,1-difluoroethane was determined to be > 472.57 mg/l based on growth inhibition.
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