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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID Dataset for CAS no: 1561-92-8
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID Dataset-European Chemicals Bureau- 18–FEB–2000

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
Principles of method if other than guideline:
Skin sensitization study was conducted in guinea pigs for test chemical sodium 2-methylprop-2-ene-1-sulfonate
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 2-methylprop-2-ene-1-sulphonate
EC Number:
216-341-5
EC Name:
Sodium 2-methylprop-2-ene-1-sulphonate
Cas Number:
1561-92-8
Molecular formula:
C4H8O3S.Na
IUPAC Name:
sodium 2-methylprop-2-ene-1-sulfonate
Details on test material:
sodium 2-methylprop-2-ene-1-sulfonate/ 1561-92-8/ 216-341-5
Specific details on test material used for the study:
- Name of test material (as cited in study report): sodium 2-methylprop-2-ene-1-sulfonate
- Molecular formula: C4H7NaO3S
- Molecular weight: 158.152 g/mol
- Substance type: Organic
- Physical state: solid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Study design: in vivo (non-LLNA)

No. of animals per dose:
20
Details on study design:
No data available
Challenge controls:
No data available
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Statistics:
No data available

Results and discussion

Positive control results:
No data available

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
No. with + reactions:
0
Total no. in group:
20
Clinical observations:
No skin sensitization reaction was observed
Remarks on result:
no indication of skin sensitisation
Remarks:
not sensitizing

Applicant's summary and conclusion

Interpretation of results:
other: not sensitizing
Conclusions:
The test material sodium 2-methylprop-2-ene-1-sulfonate (1561-92-8) was considered to be not sensitizing on guinea pigs.
Executive summary:

The skin sensitization study ofsodium 2-methylprop-2-ene-1-sulfonate (1561-92-8) was performed on 20 guinea pigs. No indication of skin sensitization was observed. Hence sodium 2-methylprop-2-ene-1-sulfonate (1561-92-8) was considered to be not sensitizing in guinea pig.