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Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
not specified
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA.
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
Prediction done using ECOSAR v.1.11 model
GLP compliance:
no
Specific details on test material used for the study:
Name of the test chemical: sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate
Molecular Formula: C12H10N3NaO5S
Molecular Weight: 331.283 g/mol
Smiles Notation: c1cc(ccc1N)Nc2ccc(cc2S(=O)(=O)[O-])[N+](=O)[O-].[Na+]
Substance type: Organic
Physical State: Solid
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: Fish
Test type:
static
Water media type:
not specified
Limit test:
no
Total exposure duration:
96 h
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
111 000 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: Not toxic
Conclusions:
On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 111000 mg/l for sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in 96 hrs. Based on the LC50 value, it can be concluded that the substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate as not toxic to aquatic environment.
Executive summary:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 111000 mg/l for sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in 96 hrs. Based on the LC50 value, it can be concluded that the substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate as not toxic to aquatic environment and thus can be considered “not classified” per the CLP criteria.

Description of key information

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 111000 mg/l for sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in 96 hrs. Based on the LC50 value, it can be concluded that the substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate as not toxic to aquatic environment and thus can be considered “not classified” per the CLP criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
111 000 mg/L

Additional information

Following study for target chemical includes predicted data from computational model developed by USEPA to conclude the

sodium 2-[(4 -aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS: 14846-08-3) toxicity extent towards fish is summarized as follows:

On the basis of EPI suite, ECOSAR version 1.1, the LC50 value for short term toxicity to fish was predicted to be 111000 mg/l for sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in 96 hrs. Based on the LC50 value, it can be concluded that the substance sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate as not toxic to aquatic environment and thus can be considered “not classified” per the CLP criteria.