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EC number: 238-906-5 | CAS number: 14846-08-3
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS no. 14846 -08 -3) is predicted using OECD QSAR tool box v.3.3 using log Kow s primary descriptor. The test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate showed 0.0 % biodegradation in aerobic condition in 28 days by considering BOD as parameter and microorganisms as inoculum. By this percent biodegradation value it is concluded that the test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate is not readily biodegradable.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846 -08 -3) .If released in to the environment, 14.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical [ sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in sediment is estimated to be 541.66 days (13000 hrs). indicates that test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate is persistent in sediment as well.
Biodegradation in Soil:
The half-life period of sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846 -08 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 85.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water:
Predicted data for target compound sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS no. 14846 -08 -3) and supporting weight of evidence studies one for its read across chemical 4-aminobenzene-1-sulfonic acid (CAS no. 121-57-3)) and another for its closest read across chemical Bis 3,3'-sulfonyldianiline (CAS no. 599-61-1) with log Kow as a primary descriptor were reviewed for the biodegradation endpoint which are summarized as below.
Biodegradability of test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS no. 14846 -08 -3) is predicted using OECD QSAR tool box v.3.3 using log Kow primary descriptor. The test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate showed 0.0 % biodegradation in aerobic condition in 28 days by considering BOD as parameter and microorganisms as inoculum. By this percent biodegradation value it is concluded that the test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate is not readily biodegradable.
Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate biodegradation potential of the test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846 -08 -3) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate is not readily biodegradable.
In a supporting weight of evidence study (D. Brown and B. Hamburger, 1987) the anaerobic biodegradation experiment was performed for read across chemical 4-aminobenzene-1-sulfonic acid (CAS no. 121-57-3) at 35oC and initial concentration of chemical taken was 100mg/L for 77 days. By DOC analysis 0 % degradation was observed in 77 days. So it is concluded that this read across chemical is not readily biodegradable.
In another supporting weight of evidence study from authoritative database (J checK, 2017) read across chemical 3, 3'-sulfonyldianiline (CAS no. 599-61-1) was subjected to biodegradation test by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analyzed by using BOD, TOC and HPLC parameter. The initial concentration of read across chemical was 100 mg/L and study design is of standard type. After 4 weeks (28 days) read across chemical 3, 3'-sulfonyldianiline showed 0% biodegradation by BOD and TOC parameter and 1% biodegradation by HPLC parameter. So it is concluded that chemical 3, 3'-sulfonyldianiline is not readily biodegradable.
On the basis of above results for target chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS no. 14846 -08 -3) from ( EPI suite 2017 and OECD QSAR tool box v3.3 2017) and for its read across substances ( from Chemosphere journal V.16 and authoritative database) the target chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS no. 14846 -08 -3) can be expected to be not readily biodegradable.
Biodegradation in water and sediment:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846 -08 -3) .If released in to the environment, 14.2 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical [ sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in sediment is estimated to be 541.66 days (13000 hrs). indicates that test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate is persistent in sediment as well.
Biodegradation in Soil:
The half-life period of sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate (CAS No: 14846 -08 -3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 85.7 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate in soil is estimated to be 120 days (2880 hrs). Based on this half-life value of test chemical sodium 2-[(4-aminophenyl)amino]-5-nitrobenzene-1-sulfonate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
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