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EC number: 216-381-3 | CAS number: 1570-64-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 7th April - 8th May 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study is to current guidelines and was performed in accordance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- PCOC
- IUPAC Name:
- PCOC
- Details on test material:
- Test substance supplied by Nufarm UK Limited.
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Cambridge Sewage Treatment Works, Cowley Road.
- Preparation of inoculum for exposure: The sludge was sieved, settled, decanted and re-suspended using mineral media.
Centrifuged at 4000rpm for 10 minutes, the supernatant discarded and re-suspended. The above step was repeated. Dry sludge solids determination was conducted on the pellet produced.
Dry sludge solids: 8.6%
Dry sludge solids in test: 0.03 g/L
Volume of mineral medium: 1.5 L per bioreactor.
- Type and size of filter used, if any: 850-micron filter. - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- > 50.4 - < 51.7 other: mg
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Test temperature: 22 +/-2 °C
- pH: not specified
- Aeration of dilution water: Atmospheric air was scrubbed clean of carbon dioxide by passing over soda lime prior to being pumped into the test system
- Continuous darkness: Yes
TEST SYSTEM
- Culturing apparatus: Conical flasks of nominal volume 2000ml.
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: CO2 free air passed through the test medium for the duration of the test.
- Measuring equipment: Tekmar-Dohrmann Phoenix 8000 (UV-Persulphate analyser).
- Details of trap for CO2 and volatile organics if used: Two CO2 traps were placed sequentially post test vessel to trap the evolved CO2.
SAMPLING
- Sampling frequency: The test medium was sampled for analysis on days 2, 5, 7, 9, 14, 19, 23, 28, 29.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Toxicity control: 51.4 mg PCOC and 102.5 mg sodium acetate.
Reference substance
- Reference substance:
- acetic acid, sodium salt
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- ca. 2
- Sampling time:
- 2 d
- Remarks on result:
- other: 28 days study but for the test substance the highest degradation was observed on day 2.
BOD5 / COD results
- Results with reference substance:
- The guideline states that the reference material must degrade by at least 60% of its Theoretical Carbon Dioxide (ThCO2) value, a maximum value of 88% degradation of the sodium acetate was achieved on day 29. This is within the guidelines.
Applicant's summary and conclusion
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the test conditions PCOC is not considered to biodegrade, however due to the stringency of the test , this does not necessarily mean that the test substance is not biodegradable under environmental conditions.
- Executive summary:
A guideline study was performed in accordance with GLP, to assess the ready biodegradability of PCOC in freshwater using the CO2 evolution test. A measured volume of inoculated mineral medium containing a known concentration of the test substance (ca 50 mg PCOC) was aerated by the passage of CO2 free air at a controlled rate and in the dark, at 22 +/-2°C. The CO2 evolved from the degradation was retained using sodium hydroxide traps. Degradation was followed over a period of 28 days by determination of the evolved CO2. The CO2 evolved is expressed as a percentage of the organic carbon in the test material.
The CO2 evolution test was also performed on a toxicity control of sodium acetate and inoculum blanks. Test and reference values were corrected for the inoculum blank as appropriate.
On day 28, 1 ml of concentrated HCl was added to drive off the remaining CO2 and a final reading made on day 29.
The results showed that the maximum degradation observed for PCOC was 2% on day 2 of the test.
60% of greater degradation relative to the theoretical CO2 value is required for a substance to be considered biodegradable. Under the conditions of the test, PCOC is not considered to be biodegradable. However due to the stringency of the test, this does not necessarily mean that the test substance is not biodegradable under environmental conditions.
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