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EC number: 212-668-2 | CAS number: 842-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Justification for type of information:
- Data is from experimental reports
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Register 38 No 187 § 1500 .41 (skin)
- Principles of method if other than guideline:
- Primary skin irritation test of 1-(Phenylazo)2-Napthol in rabbits according to Guidelines mentioned in Federal Register 38 No 187 § 1500 .41 (skin)
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-phenylazo-2-naphthol
- EC Number:
- 212-668-2
- EC Name:
- 1-phenylazo-2-naphthol
- Cas Number:
- 842-07-9
- Molecular formula:
- C16H12N2O
- IUPAC Name:
- 1-[(E)-2-phenyldiazen-1-yl]naphthalen-2-ol
- Details on test material:
- - Name of test material (as cited in study report): 1-phenylazo-2-naphthol
- Molecular formula (if other than submission substance): Not applicable
- Molecular weight (if other than submission substance): Not applicable
- Substance type: Organic
- Physical state: solid
Purity No data available
- Impurities (identity and concentrations): No data available
Constituent 1
- Specific details on test material used for the study:
- Name of test material (as cited in study report): C.I Solvent Yellow 14
Molecular formula: C16H12N2O
Molecular weight: 248.284 g/mol
Smiles notation: c12c(\N=N\c3ccccc3)c(ccc1cccc2)O
InChI: 1S/C16H12N2O/c1915111012645914(12)16(15)1817137213813/h111,19H/b1817+
Physical State: Solid
Substance type: Organic
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact and scarified
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 50% in aqueous solution
- Duration of treatment / exposure:
- 72 hours
- Observation period:
- 24 hours and 72 hours
- Number of animals:
- 6
- Details on study design:
- SCORING SYSTEM:
Draize, J .H. (1959): Dermal Toxicity. In : FDA-Appraisal of the Safety of Chemicals in Foods, Drugs And Cosmetics.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0.17
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Due to substance-induced coloration of the skin no reading and no exact calculation of the primary irritation possible at 24 hours
- Other effects:
- No data available
Any other information on results incl. tables
Results of the Primary Skin Irritation Study:
|
time |
Irritation |
Average Value |
Total Value |
|||||
Animal no. |
|||||||||
1 |
2 |
3 |
4 |
5 |
6 |
|
|
||
1. Skin reddening / corrosive |
|
|
|
|
|
|
|
|
|
Intact
|
24 h |
* |
* |
* |
* |
* |
* |
- |
- |
72 h |
- |
0 |
0 |
* |
* |
* |
0 |
0 |
|
Scarified
|
24 h |
* |
* |
* |
* |
* |
* |
- |
- |
72 h |
0 |
0 |
0 |
* |
* |
* |
0 |
0 |
|
2. Edema formation |
|
|
|
|
|
|
|
|
|
Intact
|
24 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
Scarified |
24 h |
2 |
2 |
0 |
0 |
0 |
0 |
4 |
0.67 |
72 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Primary Irritation of the skin: 0.67/4 = 0.17
*- Due to substance-induced coloration of the skin, no reading and exact calculation of the primary irritation was possible.
Skin Lesions after 8 days
Animal No |
Intact |
Scarified |
1 |
0 |
0 |
2 |
0 |
Dandruff formation |
3 |
0 |
Dandruff formation |
4 |
0 |
Dandruff formation |
5 |
0 |
0 |
6 |
0 |
Dandruff formation |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- The Primary Skin Irritation Score of 1-phenylazo-2-naphthol was 0.17.
On the basis of the scores and observations, 1-phenylazo-2-napthol can be considered as not irritating to skin. - Executive summary:
Primary skin irritation test of 1-(phenylazo)-2-napthol in rabbits was performed according to Guidelines mentioned in Federal Register 38 No 187 § 1500 .41 (skin).
6 rabbits were used for the study. 50% of the substance in aqueous solution was applied on the intact and scarfied skin of rabbits and the effects were observed at 24 and 72 hours.The reactions were scored according to Draize method.Due to substance-induced coloration of the skin no reading and no exact calculation of the primary irritation was possible at 24 hours.
Skin lesions were also observed after 8 days of testing.No lesions were observed in case of intact skin , but dandruff formation was recorded in 4 of 6 rabbits in case of scarified skin.
The Primary Skin Irritation Score of 1-phenylazo-2-naphthol was 0.17.
On the basis of the scores and observations, 1-phenylazo-2-napthol can be considered as not irritating to skin.
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