1-phenylazo-2-naphthol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Justification for type of information:

Data is from study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Principles of method if other than guideline:

Acute inhalation toxicity study of 1-phenylazo-2-naphthol (Sudanorange R) in rats

GLP compliance:

not specified

Test type:

fixed concentration procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1-phenylazo-2-naphthol

EC Number:

212-668-2

EC Name:

1-phenylazo-2-naphthol

Cas Number:

842-07-9

Molecular formula:

C16H12N2O

IUPAC Name:

1-[(E)-2-phenyldiazen-1-yl]naphthalen-2-ol

Test material form:

solid

Details on test material:

- Name of test material (as cited in study report): C. I. Solvent Yellow 14
- Molecular formula (if other than submission substance): C16H12N2O
- Molecular weight (if other than submission substance): 248.284 g/mole
- Substance type: Organic

Specific details on test material used for the study:

- Name of test material (as cited in study report): 1-phenylazo-2-naphthol (Sudanorange R)
- Molecular formula:C16H12N2O
- Molecular weight:248.284 g/mole
- Substance type:Organic
- Physical state: Solid
- Purity: 98%
- Impurities (identity and concentrations): 2%

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 °C

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

air

Remark on MMAD/GSD:

No data available

Details on inhalation exposure:

200 L of air / h are passed through a 5 cm high layer of the product.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

8 h

Remarks on duration:

for 3,10 and 30 min and 1,3 and 8 hours

Concentrations:

200 L

No. of animals per sex per dose:

12

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 8 hours

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 200 000 mg/m³ air

Based on:

test mat.

Exp. duration:

8 h

Remarks on result:

other: No mortality observed

Mortality:

No mortality observed in treated rats at 200000 mg/m3

Clinical signs:

other: No data available

Body weight:

No data available

Gross pathology:

No data available

Other findings:

No data available

Any other information on results incl. tables

Mortality x / y deceased / exposed animals

Exposure time	3'	10'	30'	1 h	3 h	8h
Steam
Volatile constituents
Staub						0/12 R

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

LC50 was considered to be > 200000 mg/m3 of air when rats were exposed with 1-phenylazo-2-naphthol (Sudanorange R) by inhalation route.

Executive summary:

In a acute inhalation toxicity study, rats were expose with 1-phenylazo-2-naphthol (Sudanorange R) in the concentration of 200000 mg/m3 / h inhaled through a 5 cm high layer of the product and observed for 8 hours. No mortality was observed in treated rat at 200000 mg/m3 / h. Therefore, LC50 was considered to be > 200000 mg/m3 of air when rats were exposed with 1-phenylazo-2-naphthol (Sudanorange R) by inhalation route.