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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from various prediction models and autoritative database
Qualifier:
no guideline available
Principles of method if other than guideline:
Prediction done using BCFBAF Program (v3.01), PBT profiler and INERIS database
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material: C.I. Solvent Yellow 14
- Molecular formula: C16 H12 N2 O
- Molecular weight: 248.284 g/mol
- Smiles notation: c12c(\N=N\c3ccccc3)c(ccc1cccc2)O
- InChl: 1S/C16H12N2O/c19-15-11-10-12-6-4-5-9-14(12)16(15)18-17-13-7-2-1-3-8-13/h1-11,19H/b18-17+
- Substance type: Organic
- Physical state: Solid
Radiolabelling:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Test temperature:
25 deg.C
Reference substance (positive control):
not specified
Key result
Temp.:
25 °C
Type:
BCF
Value:
10 L/kg
Basis:
whole body w.w.
Calculation basis:
other: No data

BCFBAF Program (v3.01) Results:

==============================

SMILES : Oc(ccc(c1ccc2)c2)c1N=Nc(cccc3)c3

CHEM : 2-Naphthalenol, 1-(phenylazo)-

MOL FOR: C16 H12 N2 O1

MOL WT : 248.29

--------------------------------- BCFBAF v3.01 --------------------------------

Summary Results:

Log BCF (regression-based estimate): 1.00 (BCF = 10 L/kg wet-wt)

Biotransformation Half-Life (days) : 1.67 (normalized to 10 g fish)

Log BAF (Arnot-Gobas upper trophic): 2.83 (BAF = 670 L/kg wet-wt)

Log Kow (experimental): not available from database

Log Kow used by BCF estimates: 5.51

Equation Used to Make BCF estimate:

Log BCF = 1.00 { Aromatic Azo Specification }

Correction(s): Value

Aromatic Azo compound 0.000

Estimated Log BCF = 1.000 (BCF = 10 L/kg wet-wt)

Validity criteria fulfilled:
not specified
Conclusions:
Based on the predicted data by BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C.
Executive summary:

Based on the predicted data by BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C.Based on the BCF concentration it is concluded that the test chemical 1-phenylazo-2-naphthol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

Description of key information

Based on the predicted data by BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical 1-phenylazo-2-naphthol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

Key value for chemical safety assessment

BCF (aquatic species):
10 L/kg ww

Additional information

Bioaccumulation: aquatic / sediment

Experimental and estimated data of Bioaccumulation property for the target chemical 1-phenylazo-2-naphthol (CAS No. 842-07-9) and its read across chemical were reviewed to summarize as follows:  

 

From predicted model EPI suite 2017 using BCFBAF Program (v3.01) model,PBT profiler and INERIS database the Bioaccumulation factor (BCF) was predicted to be 10 L/kg wet-wt at 25 deg.C.Based on the BCF concentration it is concluded that the test chemical 1-(phenyldiazenyl)-2-naphthol is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000. 

 

From HSDB database; 2017 the read across chemical Sodium 4-[(4-hydroxy-1-naphthyl)azo] benzene sulphonate i.e C.I. ACID ORANGE 20 (CAS No. 523-44-4) indicate an estimated BCF value of 0.5 was calculated for C.I. Acid Orange 20, using an estimated log Kow of -0.14 and a recommended regression-derived equation. According to a classification scheme, this BCF value suggests that bioconcentration in aquatic organisms is low.

 

Data for another read across Orange G (CAS No. 1936-15-8) from same database i.e HSDB indicate that the estimated BCF value of 0 was calculated for Orange G, using an estimated log Kow of -4.56 and a recommended regression-derived equation. This BCF value suggests that bioconcentration of Orange G in aquatic organisms will not be an important fate process.

 

Similarly information for another read across C.I. Food Yellow 3 (CAS No. 2783-94-0) indicates the ionic character of C.I. Food Yellow 3 suggests the potential for bioconcentration in aquatic organisms is expected to be low.

 

Thus, based on the above all studies it is concluded that the test substance 1-phenylazo-2-naphthol (CAS No. 842-07-9) is non bioaccumulative in aquatic environment.