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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Data is from experimental report.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Principles of method if other than guideline:
The water solubility determination of test item 1-phenylazo-2-naphthol (CAS No. 842-07-9) was done as per the OECD guideline 105 by spectrophoto metric analytical method as per OECD 101.
GLP compliance:
not specified
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source: SUSTAINABILITY SUPPORT SERVICES (EUROPE) AB
- Batch No.of test material: 0009
- Expiration date of the lot/batch: 17/04/2021
- Physical Appearance: orange to orange red powder

RADIOLABELLING INFORMATION (not applicable)
- Radiochemical purity: N/A
- Specific activity: N/A
- Locations of the label: N/A
- Expiration date of radiochemical substance: N/A

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material:Ambient Temp (23 to 27 °C) (Store in a cool, dry, well ventilated place. Keep in a fireproof place. Keep away from strong bases, strong acids, sources of heat, ignition and direct sunlight).
- Stability under test conditions: Stable in recommended storage conditions.
- Solubility and stability of the test substance in the solvent/vehicle: no data available
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: no data available

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: no data available
- Preliminary purification step (if any): no data available
- Final dilution of a dissolved solid, stock liquid or gel: no data available
- Final preparation of a solid: no data available

OTHER SPECIFICS:
- Precautions: Wear respiratory protection. Avoid contact with skin and eyes. Avoid dust formation. Avoid breathing dust, fume, vapours, mist, spray or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Use only in a chemical fume hood.
Key result
Water solubility:
0.018 mg/L
Conc. based on:
test mat.
Temp.:
30 °C
Remarks on result:
other: substance is insoluble in water
Details on results:
The water solubility for the test item 1-phenylazo-2-naphthol was found to be 0.01845 mg/L at 30°C.

Table 2:

Sample Stirring time (hours)

Concentration obtained on the basis of the standard curve (mg/l)

Dilution Factor

Solubility value obtained (mg/l)

24

-

-

-

48

 -

 -

 -

72

 -

 -

 -

Considering the water solubility for 48 hrs and 72 hrs the mean water solubility was calculated as follows:

Mean water solubility value for 48 hour run sample + 72 hour run sample

=-

= 0.01845 mg/L

Conclusions:
The water solubility determination of test item 1-phenylazo-2-naphthol;CAS No.842-07-9 was done by spectrophotometric method. The water solubility was found to be 0.01845 mg/L at 30°C.


Executive summary:

The water solubility determination of test item 1-phenylazo-2-naphthol (CAS No. 842-07-9) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of (1-phenylazo-2-naphthol of 842-07 -9 )in water was found to be 0.01845 mg/L at 30°C.Thus, it can be concluded that 1-phenylazo-2-naphthol is insoluble in water.

Description of key information

The water solubility determination of test item 1-phenylazo-2-naphthol;CAS No.842-07-9 was done by spectrophotometric method. The water solubility was found to be 0.01845 mg/L at 30°C.

Key value for chemical safety assessment

Water solubility:
0.018 mg/L
at the temperature of:
25 °C

Additional information

The water solubility determination of test item 1-phenylazo-2-naphthol (CAS No. 842-07-9) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of (1-phenylazo-2-naphthol of 842-07 -9 )in water was found to be 0.01845 mg/L at 30°C.Thus, it can be concluded that 1-phenylazo-2-naphthol is insoluble in water.

Based on the data from various handbooks and modelling databases suggests that the estimated water solubility of 1-phenylazo-2-naphthol at 25 deg C was 0.6738 mg/l. This indicates that 1-phenylazo-2-naphthol is insoluble to very slightly soluble in water.

As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of water solubility as 0.01845 at 30 degC, indicating the substance to be insoluble in water, thus considered as key study for the chemical safety assessment.