Registration Dossier
Registration Dossier
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EC number: 939-185-6 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- The justification for the read across category approach is included in IU section 13.
Data source
Materials and methods
Test material
- Reference substance name:
- Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
- EC Number:
- 939-185-6
- Molecular formula:
- C8H11(CH2)nSO3 n=19-23
- IUPAC Name:
- Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
- Test material form:
- liquid: viscous
- Details on test material:
- Appearance: viscous opaque suspension
Constituent 1
Results and discussion
Test results
- Species / strain:
- Chinese hamster Ovary (CHO)
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- >= 15 µg/ml with S9, >= 58 µg/ml without S9
- Vehicle controls validity:
- not examined
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
Applicant's summary and conclusion
- Conclusions:
- No geneitic toxicity study with the target substance is available. Data generated with the cateogry substance LABS Na is considered pivotal to this endpoint. LABS NA is not clastogenic in the absence of metabolic activation. THe test substance is also not clastogenic in the presence of metabolic activation at non-cytotoxic concentrations. At cytotoxic xoncentrations, the test substance was weakly clastogenic. The target substance is considered to be not mutagenic.
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