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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

in vitro cytogenicity / chromosome aberration study in mammalian cells
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
The justification for the read across category approach is included in IU section 13.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
EC Number:
Molecular formula:
C8H11(CH2)nSO3 n=19-23
Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
Test material form:
liquid: viscous
Details on test material:
Appearance: viscous opaque suspension

Results and discussion

Test results
Species / strain:
Chinese hamster Ovary (CHO)
Metabolic activation:
with and without
Cytotoxicity / choice of top concentrations:
>= 15 µg/ml with S9, >= 58 µg/ml without S9
Vehicle controls validity:
not examined
Untreated negative controls validity:
Positive controls validity:
Remarks on result:
other: all strains/cell types tested

Applicant's summary and conclusion

No geneitic toxicity study with the target substance is available. Data generated with the cateogry substance LABS Na is considered pivotal to this endpoint. LABS NA is not clastogenic in the absence of metabolic activation. THe test substance is also not clastogenic in the presence of metabolic activation at non-cytotoxic concentrations. At cytotoxic xoncentrations, the test substance was weakly clastogenic. The target substance is considered to be not mutagenic.