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EC number: 939-185-6
CAS number: -
No study on skin sensitisation is available with the test substance.
Data generated with the category substances LABS and LABS Na were
considered to be pivotal datasets to assess this endpoint. The test
substance is considered not sensitising to skin and therefore not to be
skin sensitisation study is available with the target substance. The
data generated with the category substances LABS and LABS Na are
considered pivotal datasets within the category to assess this endpoint.
group of 10 male and 10 female guinea pigs were used to determine the
potential of LABS to be sensitising to skin according to test protocol
from Magnusson, B., and Kligman, A.M. (1969) study. The animals were
first given an intradermal induction of 0.05% of test substance in corn
oil. One week later, they were given a dermal induction of 5% test
substance in corn oil. A group of 5 male and 5 female guinea pigs were
used as controls. These animals were treated in a similar fashion with
vehicle only. Two weeks after the dermal induction, a challenge was
performed via dermal exposure to 2.5% test substance in corn oil. The
control group was exposed as well. The animals were exposed for 24 hrs.
Skin irritation readings were made at 24 and 48 hrs after the end of
exposure. No positive responses were seen in either the test or control
group. The test substance is not sensitising to skin.
guinea pig maximization test was performed with LABS Na to determine the
skin sensitisation potential. Ten male and ten female guinea pigs were
given intradermal injections of 25% test solution. Control animals (5
male and 5 female) were given injections of vehicle only. One week
later, a second induction was done by dermal exposure to 25% test
solution for 24 hrs. Control animals were again exposed to vehicle only.
On day 21, the challenge exposure was performed. All animals were
exposed to 12.5% test solution dermally. Exposure was for 24 hrs, with
observations made at 48 and 72 hrs after the start if exposure. No
positive reactions were noted. The test substance is not sensitizing.
The target substance is considered to be non sensitising to skin and
therefore not to be classified according to CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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