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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
The justification document on the read across category approach is included in IUCLID section 13.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
EC Number:
939-185-6
Molecular formula:
C8H11(CH2)nSO3 n=19-23
IUPAC Name:
Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
Test material form:
liquid: viscous
Details on test material:
Appearance: viscous opaque suspension

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1, 24, 48, 72 hrs and 6 days
Score:
46.9
Reversibility:
not fully reversible within: 6 days
Remarks on result:
other: the test substance LABS was moderately irritating but because of intensity of necrosis formation, the study was stopped at day 6. The test substance is considered corrosive

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
There is no eye irritation study available with the target substance. Data generated with the category substance LABS is considered pivotal to this endpoint and is the conservative approach. LABS is considered to be classified as category 1 (serious eye damage 1) and thus also the target substance will be classified as category 1. .

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