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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
The short-term toxicity to aquatic invertebrates can be predicted by read across to the alkyl benzene derivitatives category from which the conclusion can be drawn that an increasing carbon chain length causes a decrease in water solubility. Based on this, it can be expected that the short-term toxicity to aquatic invertebrates for benzene sulfonic acid, C20-24 will be very low. Though as a worst case approach, the result of the category member with the highest water solubility value is used as a boundary value. The read across justification document is attached in IUCLID section 13.
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
2.4 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality
Conclusions:
No chronic fish study with the target substance is available. Data generated with the category substance LABS Na is considered pivotal to this endpoint and this is the most conservative approach. The 48-h LC50 of the target substance can be considered 2.4 mg/L, based on read across to the group alkyl benzene derivatives (worst case approach).

Description of key information

No data on acute toxicity to aquatic invertebrates is available for the target substance.  Structural analogues (alkylbenzene derivatives) were used to understand the acute toxicity profile of substance to daphnia. A study from LABS Na (CAS no: 68411-30-3) was used to cover this endpoint. Using a conservative approach, the 48-hr EC50 was set to 2.4 mg a.i/L. The target substance however has a very low water solubility demonstrated by QSAR modelling. .According to data from a category substance and QSAR modelling of the target substance, indicating an extremely low water solubility, the substance does not demonstrate acute aquatic toxicity to daphnia at water soluble concentrations.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
2.4 mg/L

Additional information

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