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EC number: 813-338-6 | CAS number: 106155-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
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- Particle size distribution (Granulometry)
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- Endpoint summary
- Stability
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
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- Acute Toxicity
- Irritation / corrosion
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- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
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- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 13th of August to 28th of November, 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Test conducted in GLP according to the version of the OECD guideline 471 applicable then. However under the currently version of the guideline it is also required to include Salmonella typhimurium TA102 and/or Escherichia coli WP2 or E.coli WP2 (pKM101)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- (E)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol
- Cas Number:
- 106155-02-6
- Molecular formula:
- C13H22O
- IUPAC Name:
- (E)-2-methyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)but-2-en-1-ol
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 1538
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 mix
- Test concentrations with justification for top dose:
- 1st experiment: 8; 40; 200; 1000 and 5000 µg/plate
2nd experiment: 5, 10, 20, 50 and 100 µg/plate
Controlsopen allclose all
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO and the untreated fresh cell suspensions served as negative control
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- sodium azide
- other: 4-nitro-o-phenylendiamine
- Remarks:
- As positive controls, sodium azide was used in the tester strains TA 100 and TA 1535, 9-aminoacridine in the tester strain TA 1537, and 4-nitro-o-phenylendiamine in the tester strains TA 98 and TA 1538 without microsomal drug-metabolizing enzymes (S9-mix)
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO and the untreated fresh cell suspensions served as negative control
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: The enzyme activity of the Aroclor 1254 induced S9 fractions was controlled by testing with 2-aminoanthracene in all strains.
- Remarks:
- The enzyme activity of the S9 fractions was controlled by testing with 2-aminoanthracene in all strains.
Results and discussion
Test resultsopen allclose all
- Key result
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- see table 1, 2 & 3
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Key result
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- see table 1, 2 & 3
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Additional information on results:
- The test item was tested in two independent test series at a concentration range of 5.0 - 5000 µg/plate (first and second test).
The test item was tested in the absence and presence of Aroclor 1254-induced S9-mix. In both test series (Tables 1 - 2) the plates were incubated for 48 hours at 37° C.
The findings show that the test item did not induce any reverse mutations in the absence of rat liver enzymes (without S9-mix), nor did occur any induced reverse mutations in the presence of Aroclor 1254-induced S9-mix (with S9-mix).
Toxic effects were noted, starting at a concentration of 40 µg/plate without S9-mix and above 200 µg/plate with S9-mix. Precipitations were not noted. The summarized results are presented in table 3. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- In the described mutagenicity test and under the experimental conditions reported, the test item did not induce point mutations by base-pair changes or frameshifts in the genome of the strains used.
Therefore the test item is not considered to be mutagenic in this Salmonella typhimurium reverse mutation assay. - Executive summary:
In conclusion, it can be stated that during the described mutagenicity test and under the experimental conditions reported, the test item did not induce point mutations by base-pair changes or frameshifts in the genome of the strains used.
Therefore, the test item is not considered to be mutagenic in this Salmonella typhimurium reverse mutation assay.
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