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EC number: 813-338-6 | CAS number: 106155-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 5th April 2016 to 9th September 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.082
- Temp.:
- 25 °C
- pH:
- >= 6.5 - <= 6.63
- Conclusions:
- SUMMARY
Title of Study: Determination of the log POW of Sandalmysore Core ac-cording to OECD 107 resp. EU A.8
Findings and Results:
The study was performed using the flask method. Partition coefficient was determined using n-octanol and water.
Three volume ratios of n-octanol:water (2:10, 4:10 and 1:10) were tested in duplicate.
The separated phases were analysed using HPLC as described in chapter 6.4.
The measurements of the phases gave the following log POW of the test item at the respective ratio:
Table 3-a Results
Ratio octanol:water Mean log POW Standard Deviation
2:10 4.056 Not applicable*
4:10 4.026 0.021
1:10 4.151 0.007
* One replicate was lost during workup
The log POW of the test item was determined as 4.082 ± 0.059 (mean value ± standard deviation) - Executive summary:
The study was performed using the flask method. Partition coefficient was determined using n-octanol and water.
Three volume ratios of n-octanol:water (2:10, 4:10 and 1:10) were tested in duplicate. The separated phases were analysed using HPLC.
The measurements of the phases gave the following log POW of the test item at the respective ratio:
Ratio octanol:water
Mean log POW
Standard Deviation
2:10
4.056
Not applicable*
4:10
4.026
0.021
1:10
4.151
0.007
* One replicate was lost during workup
The log POW of the test item was determined as 4.082 ± 0.059 (mean value ± standard deviation)
Reference
Results and Validity
Overview of Determinations
The POWfor each determination, the mean, standard deviation and relative standard deviation of the six determinations are presented in the following table.
Table10.1–a POW
Step |
POW |
Mean POW Step |
Mean POW |
Relative |
1a |
4509* |
11372 |
12189 |
15.4 % |
1b |
11372 |
|||
2a |
10105 |
10620 |
||
2b |
11135 |
|||
3a |
14398 |
14165 |
||
3b |
13933 |
* Replicate 1a was considered as outlier, carryover of octanol phase was suspected.
The log POWfor each determination, the mean, standard deviation and relative standard deviation of the six determinations at the three pHs is presented in the following table.
Table10.1–b log POW
Step |
log POW |
Mean log POW |
Range |
Relative |
1a |
3.654* |
4.082 |
4.005 – 4.158 |
1.6 % |
1b |
4.056 |
|||
2a |
4.005 |
|||
2b |
4.047 |
|||
3a |
4.158 |
|||
3b |
4.144 |
* Replicate 1a was considered as outlier, carryover of octanol phase was suspected.
log POW
The log POWof the test itemSandalmysore Corewas calculated as (log POW± standard deviation):
4.082 ± 0.059
Validity
The six log POWs should lie in a range of ± 0.3 units.
The range was smaller than 0.2 log POWunits.
Description of key information
The study was performed using the flask method. Partition coefficient was determined using n-octanol and water.
Three volume ratios of n-octanol:water (2:10, 4:10 and 1:10) were tested in duplicate. The separated phases were analysed using HPLC.
The measurements of the phases gave the following log POW of the test item at the respective ratio:
Ratio octanol:water |
Mean log POW |
Standard Deviation |
2:10 |
4.056 |
Not applicable* |
4:10 |
4.026 |
0.021 |
1:10 |
4.151 |
0.007 |
* One replicate was lost during workup
The log POW of the test item was determined as 4.082 ± 0.059 (mean value ± standard deviation)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.082
- at the temperature of:
- 25 °C
Additional information
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