Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: GLP guideline study - only preliminary testing was performed

Data source

Reference
Reference Type:
other: Report
Title:
Unnamed
Year:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Remarks:
only non-GLP preliminary testings were performed

Test material

Constituent 1
Chemical structure
Reference substance name:
2-piperidin-2-ylethanol
EC Number:
216-059-2
EC Name:
2-piperidin-2-ylethanol
Cas Number:
1484-84-0
Molecular formula:
C7H15NO
IUPAC Name:
2-piperidin-2-ylethanol
Constituent 2
Reference substance name:
2-Piperidineethanol
IUPAC Name:
2-Piperidineethanol

Results and discussion

Water solubility
Water solubility:
ca. 572 g/L
Temp.:
20 °C
Remarks on result:
other: mean value - The water solubility of the TS was determined to be 572 g/L (20°C; >556 g/L, <588 g/L)

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the TS was determined to be 572 g/L (20°C; >556 g/L, <588 g/L)
As the application dose would have been at least 2940 g/L(water), fivefold of the maximum solubility determined in the preliminary test, sufficient stirring of the mixtures is not possible. Therefore, the performance of a definitive testing according to the guideline was not tested.

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