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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
review article or handbook
Title:
Acute Toxicity
Author:
German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety and the Environmental Ministries of all 16 Federal States of Germany (Länder)
Year:
1996
Bibliographic source:
GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States; GSBL Datenlieferung Sommer 1996

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as per mentioned below
Principles of method if other than guideline:
Acute oral toxicity performed on rat by using test chemical 3'-aminoacetophenone
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 3’-aminoacetophenone
- Molecular formula: C8H9NO
- Molecular weight: 135.16 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
Source: No data
Age at study initiation: No data
Weight at study initiation: 90 -120 g
Fasting period before study: Not fasted
Housing: No data
Diet (e.g. ad libitum): No data
Water (e.g. ad libitum): No data
Acclimation period: No data

ENVIRONMENTAL CONDITIONS
Temperature (°C): No data
Humidity (%):No data
Air changes (per hr): No data
Photoperiod (hrs dark / hrs light): No data

IN-LIFE DATES: From: No data To: No data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: It was necessary to bring the volume administered per rat in 1ml to 10 ml, the substance was dissolved in water, corn oil or 1% Tergitol 7 Penetrant (an aqueous solution of 25% 3 Sodium,9diethyl6tridecanolsulfat)
Details on oral exposure:
VEHICLE
Concentration in vehicle: It was necessary to bring the volume administered per rat in 1ml to 10 ml
Amount of vehicle (if gavage): 1 -10 ml
Justification for choice of vehicle: No data
Lot/batch no. (if required): No data
Purity: No data

MAXIMUM DOSE VOLUME APPLIED:
No data
Doses:
Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage.
No. of animals per sex per dose:
5 males/ dose
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days (or other?) : 14 days
Statistics:
Based on the occurring during this time
Mortalities were statistically the most likely
LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.

Results and discussion

Preliminary study:
no data
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 870 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mortality
Mortality:
no data
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
For the study 90- 120g male Carworth Wistar rats, were used. Each dose group contained 5 rats. Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage. The animals had not previously fasted. A total of 157 substances were investigated. The work does not contain information about which substances and which were tested undiluted in dissolved or suspended form.
Based on the occurring during this time, Mortalities were statistically the most likely LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.
The acute oral LD50 value for 3’-aminoacetophenone in rats is 1870mg/kg
Executive summary:

For the study 90- 120g male Carworth Wistar rats, were used. Each dose group contained 5 rats. Doses differed in logarithmic sequence by a factor of 2. The substance was given as a single dose by gavage. The animals had not previously fasted. A total of 157 substances were investigated. The work does not contain information about which substances and which were tested undiluted in dissolved or suspended form.

 It was necessary to bring the volume administered per rat in 1ml to 10 ml, the substance was dissolved in water, corn oil or 1% Tergitol 7 Penetrant (an aqueous solution of 25% 3 Sodium,9diethyl6tridecanolsulfat)

After administration of the test chemical the rats were observed for 14 days.

Based on the occurring during this time, Mortalities were statistically the most likely LD50 value and the confidence level by the method of Thompson using the Tables of Weil determined.

The acute oral LD50 value for 3’-aminoacetophenone in rats is 1870mg/kg