Registration Dossier
Registration Dossier
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EC number: 202-722-3 | CAS number: 99-03-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 99-03-6
- Author:
- Danish (Q)SAR Database
- Year:
- 2 016
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.
Materials and methods
- Principles of method if other than guideline:
- The predicton is done using Danish (Q)SAR Database
- GLP compliance:
- no
- Type of study:
- other: Allergic contact dermatitis (ACD) in guinea pig and human
Test material
- Reference substance name:
- 3'-aminoacetophenone
- EC Number:
- 202-722-3
- EC Name:
- 3'-aminoacetophenone
- Cas Number:
- 99-03-6
- Molecular formula:
- C8H9NO
- IUPAC Name:
- 1-(3-aminophenyl)ethan-1-one
- Details on test material:
- Name of test material: 3’-aminoacetophenone
- Molecular formula: C8H9NO
- Molecular weight: 135.16 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
In vivo test system
Test animals
- Species:
- other: guinea pig and human
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- no data
Challengeopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- no data
- No. of animals per dose:
- no data
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- not sensitising
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: not sensitising.
Any other information on results incl. tables
not sensitising
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization was estimated to be negative on guinea pig and human for 3'-aminoacetophenone. Thus it can be concluded that the substance 3'-aminoacetophenone has negative skin sensitization effects and based on the CLP criteria for classification it can be classified as not sensitizing to skin.
- Executive summary:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the skin sensitization was estimated to be negative on guinea pig and human for 3'-aminoacetophenone. Thus it can be concluded that the substance 3'-aminoacetophenone has negative skin sensitization effects and based on the CLP criteria for classification it can be classified as not sensitizing to skin.
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