Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 99-03-6
Author:
Danish (Q)SAR Database
Year:
2016
Bibliographic source:
Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Predicted data
Principles of method if other than guideline:
Data is predicted using the Danish (Q)SAR Database
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 3’-aminoacetophenone
- Molecular formula: C8H9NO
- Molecular weight: 135.16 g/mol
- Substance type: Organic
- Physical state: Liquid

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h
Post exposure observation period:
No data

Test conditions

Hardness:
No data
Test temperature:
No data
pH:
No data
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
No data
Details on test conditions:
No data
Reference substance (positive control):
not specified

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
39.033 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
No data
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the LC50 was estimated to be 39.0334 mg/kg bw on daphnia magna for substance 3'-aminoacetophenone
Executive summary:

Based on the QSAR prediction done using the Danish (Q)SAR Database, the LC50 was estimated to be 39.0334 mg/kg bw on daphnia magna for substance 3'-aminoacetophenone