Registration Dossier
Registration Dossier
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EC number: 209-795-0 | CAS number: 593-51-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- INHALATION TOXICOLOGY OF METHYLAMINE
- Author:
- A. Kinney, R. Valentine, H. C. Chen, R. M. Everett, and G. L. Kennedy
- Year:
- 1 990
- Bibliographic source:
- Inhalation Toxicology, 2:29-39, 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the ocular irritation potential of Methylamine hydrochloride in rabbits
- GLP compliance:
- no
Test material
- Reference substance name:
- Methylammonium chloride
- EC Number:
- 209-795-0
- EC Name:
- Methylammonium chloride
- Cas Number:
- 593-51-1
- Molecular formula:
- CH5N.ClH
- IUPAC Name:
- methanamine
- Reference substance name:
- Methylamine hydrochloride
- IUPAC Name:
- Methylamine hydrochloride
- Test material form:
- solid
- Details on test material:
- - Name of test material: Methylamine hydrochloride
- Molecular formula: - CH5N.ClH
Molecular weight: 67.5184 g/mol
- Smiles notation: C[NH3+].[ClH-]
- InChl: 1S/CH5N.ClH/c1-2;/h2H2,1H3;1H
- Substance type: Organic
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- - Name of test material: Methylammonium chloride
- Molecular formula: CH5NClH
- Molecular weight: 67.5184 g/mol
- Smiles notation: C[NH3+].[ClH-]
- InChl: 1S/CH5N.ClH/c1-2;/h2H2,1H3;1H
- Substance type: Organic
- Physical state: Solid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data available.
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 40% solution of mehtylamine hydrochloride
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 24 hours
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- No data available.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Max. score:
- 0
- Reversibility:
- fully reversible within: 24 hours
- Remarks on result:
- probability of mild irritation
- Irritant / corrosive response data:
- mild irritation was observed which was not noted 24 h later
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- A 40% aqueous solution of methylamine hydrochloride was instilled into the rabbit eyes. It produced mild irritation,which was not noted 24 h later.
Since the effects were reversible within 24 hours, Methylamine hydrochloride can be considered to be not irritating to eyes - Executive summary:
Eye irritation test was conducted in rabbits to assess the irritation potential of Methylamine hydrochloride.
A 40% aqueous solution of methylamine hydrochloride was instilled into the rabbit eyes. It produced mild irritation,which was not noted 24 h later.
Since the effects were reversible within 24 hours, Methylamine hydrochloride can be considered to be not irritating to eyes
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