Registration Dossier
Registration Dossier
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EC number: 209-795-0 | CAS number: 593-51-1
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment:
From BCFBAF Program (v3.00) model of EPI suite the estimated bio concentration factor (BCF) for Methylamine hydrochloride is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that chemical Methylamine hydrochloride is not expected to be bioaccumulative in fish and the food chain.
Additional information
Bioaccumulation: aquatic / sediment:
Three different studies including those from validated prediction databases and experimental study for bioaccumulation endpoint of target chemical Methylamine hydrochloride (Cas no. 593-51-1) and relevant read across which is basic structure of the target chemical are summarized as followed:
Prediction done using the BCFBAF (v3.00) model of EPI Suite program indicated the estimated bio concentration factor (BCF) for Methylamine hydrochloride as 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.
Another prediction database PBT profiler proposed the Bioaccumulation factor (BCF) was predicted to be 3.2 L/kg wet-wt at 25 deg.C for test chemical Methylamine hydrochloride.
Further, an experimental study of basic structure chemical Monomethylamine or methylamine (Cas no. 74-89-5) supports the above predicted results of target substance. It suggested an estimated BCF of 3 was calculated in fish for methylamine, using a log Kow of -0.57 and a regression-derived equation. This BCF suggests the potential for bioconcentration in aquatic organisms is low. (HSDB database; 2017)
All values for bioaccumulation is in the range of 3 -3.2 (L/kg or dimensionless) conclude that the target chemical Methylamine hydrochloride (Cas no. 593-51-1) is not expected to be bioaccumulative in fish and the food chain.
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