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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from experimental reports

Data source

Reference
Reference Type:
publication
Title:
Safety Assessment of alpha-amino acids as used in Cosmetics
Author:
Burnett, C.L., Heldreth, B., Bergfeld, W.F., Belsito, D.V., Hill, R.A., Klaassen, C.D., Liebler, D.C., Marks Jr, J.G., Shank, R.C., Slaga, T.J. and Snyder, P.W.
Year:
2013
Bibliographic source:
International Journal of Toxicology, 32(6_suppl), pp.41S-64S; 2013

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: Draize method
Principles of method if other than guideline:
To assess the dermal irritation potential of L-Arginine in rabbits according to Draize method
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Arginine
EC Number:
200-811-1
EC Name:
Arginine
Cas Number:
74-79-3
Molecular formula:
C6H14N4O2
IUPAC Name:
L-Arginine
Test material form:
solid
Details on test material:
Name of the test chemical:
Molecular Formula:C6H14N4O2
Molecular Weight:174.20 g/mol
Substance Type: organic
Physical State: Solid
InChI: 1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
Specific details on test material used for the study:
Name of the test chemical:
Molecular Formula:C6H14N4O2
Molecular Weight:174.20 g/mol
Substance Type: organic
Physical State: Solid
InChI: 1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

Test animals

Species:
rabbit
Strain:
other: New Zealand
Details on test animals or test system and environmental conditions:
sex: male

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
5% in distilled water
Duration of treatment / exposure:
no data available
Observation period:
no data available
Number of animals:
4
Details on study design:
no data available

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no Irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
L-Arginine was observed to be not irritating to the skin of male New Zealand albino rabbits.
Executive summary:

The dermal irritation potential of L-Arginine in New Zealand albino rabbits was assessed according to Draize method.

L-Arginine was applied as 5% solution in distilled water to the skin of 4 male New Zealand albino rabbits and effects were observed (duration not specified).

L-Arginine was observed to be not irritating to the skin of male New Zealand albino rabbits.