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Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

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Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: comparable to guideline study with acceptable restrictions (no analytical monitoring of the test concentrations, no purity of the test substance given)
Qualifier:
equivalent or similar to guideline
Guideline:
other: in analogy to the rules of the Dutch Standard Organization (NEN Nederlands Normalisatie Institut, 1980))
GLP compliance:
no
Analytical monitoring:
no
Details on sampling:
No data shown
Vehicle:
no
Details on test solutions:
No data shown
Test organisms (species):
Daphnia magna
Details on test organisms:
the test organisms were 1 day old and were obtained from standardized laboratory cultures
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
No data shown
Hardness:
No data shown
Test temperature:
The temperature was 19 +/-1 °C during the experiment.
pH:
No data shown
Dissolved oxygen:
No data shown
Nominal and measured concentrations:
Test conecntrations were nominal
Details on test conditions:
Lightining was circadic; number of organisms per group 25.
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
1 000 - 1 800 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
NAS-a
Basis for effect:
mortality
Details on results:
No data shown
Results with reference substance (positive control):
No data shown
Reported statistics and error estimates:
No data shown

The LC50 values were observed in the concentration interval between 1000 and 1800 mg/L.

Validity criteria fulfilled:
not applicable
Conclusions:
The test material NAS-a showed a relatively low acute toxicity to the selected test species Daphnia Magna with the LC50 ranging from 1000 and 1800 mg/L
Executive summary:

The short-term toxicity of sodium aluminium silicate (NAS-a) to the fresh water invertebrate species Daphnia Magna was examined in accordance to the Dutch Standard Organization (NEN Nederlands Normalisatie Institut, 1980) guidelines which is similar to the OECD 202 guideline.

A 48 hours toxicity test was performed on 25 organisms per gorup from standardized laboratory cultures. The concentrations were nominal during the experiment and the LC50 value was determined according to Litchfield and Wilcoxon method. The tests were conducted under controlled temperature conditions at 19 ± 1°C with a circadiac light:dark cycle. Dosing was performed under static conditions. NAS-a showed low toxicity to the selected species with the LC50 being in the intervals between 1000 and 1800 mg/L.

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: comparable to guideline study with acceptable restrictions (no analytical monitoring of the test concentrations, no purity of the test substance given)
Qualifier:
equivalent or similar to guideline
Guideline:
other: in analogy to the rules of the Dutch Standard Organization (NEN Nederlands Normalisatie Institut, 1980))
GLP compliance:
no
Analytical monitoring:
no
Details on sampling:
No data shown
Vehicle:
no
Details on test solutions:
No data shown
Test organisms (species):
other aquatic arthropod: Aedes aegypti
Details on test organisms:
The test organisms were 3&4 weeks obtained from standardized laboratory cultures
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Post exposure observation period:
No data shown
Hardness:
No data shown
Test temperature:
The test temperature was 23 +/-2 °C during the experiment
pH:
No data shown
Dissolved oxygen:
No data shown
Salinity:
No data shown
Nominal and measured concentrations:
Test concentrations were nominal.
Details on test conditions:
Lightining was circadic; number of organisms per group 10.
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
10 000 - 18 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
NAS-a
Basis for effect:
mortality
Details on results:
No data shown
Results with reference substance (positive control):
No data shown
Reported statistics and error estimates:
No data shown

The LC50 values were observed in the concentration interval between 10000 and 18000 mg/L.

Validity criteria fulfilled:
not applicable
Conclusions:
The test material NAS-a showed a relatively low acute toxicity to the selected test species Aedes Aegipti with the LC50 ranging from 10000 and 18000 mg/L
Executive summary:

The short-term toxicity of sodium aluminium silicate (NAS-a) to the aquatic arthropod species Aedes Aegipti

was examined in accordance to the Dutch Standard Organization (NEN Nederlands Normalisatie Institut, 1980). A 48 hours toxicity test was performed on 10 organisms per gorup from standardized laboratory cultures. The Litchfield and Wilcoxon method was used to derive the LC50 and effect concentrations were nominal. The tests were conducted under controlled temperature conditions at 23 ± 2°C with a circadiac light:dark cycle Dosing was performed under static conditions. NAS-a showed low toxicity to the selected species with the LC50 being in the intervals between 10000 and 18000 mg/L.

Description of key information

The read-across substance, NAS-a, showed low toxicity to the aquatic arthropod species Aedes Aegipti and to the fresh water invertebrate species Daphnia Magna with the LC50 being in the intervals between 10000 and 18000 mg/L and in the intervals between 1000 and 1800 mg/L respectively. It is proposed to use the most conservative LC50 (1000 mg/L for Daphnia Magna and 10000 mg/L for Oryzias Aedes Aegipti) for the purpose of the classification. Therefore, NAS-a is not considered to be toxic to aquatic invertebrates based on the finding of this study.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1 000 mg/L

Additional information

The acute toxicity of the read-across substance, NAS-a, to aquatic invertebrates was determined in accordance with rules of Dutch Standard Organization (NEN Nederlands Normalisatie Institut, 1980) which is similar to the OECD 202 guideline. The freshwater aquatic invertebrate Daphnia Magna and the aquatic arthropod species Aedes Aegipti were exposed to the test concentration which killed 50% of the test species over 48 hours (LC50). The concentrations were nominal during the experiment and the LC50 value was determined according to Litchfield and Wilcoxon method. NAS-a showed to be not toxic to Daphnia Magna under the conditions of this study with the LC50 being in the intervals between 1000 and 1800 mg/L. Similarly, the substance was also found to be not toxic to aquatic arthropod species Aedes Aegipti with the LC50 being in the intervals between 10000 and 18000 mg/L. Read-across between the registered substance and the test substance is considered justified owing the structural similarity of the two substances. The registered substance and NAS-a will release silicon, aluminium, and respectively magnesium and sodium. As NAS-a is more water soluble than Cordierite, its aquatic toxicity represents the worst case scenario.