Registration Dossier
Registration Dossier
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EC number: 931-468-2 | CAS number: 1190625-94-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Section 9.3.2. of Column 2 of Annex IX of the REACH regulation, the registrant proposes to waive the testing on bioaccumulation in aquatic species, preferably fish, as the results of the chemical safety assessment indicate that the substance is not considered to have the potential to be either directly or indirectly released to the aquatic environment. However further reassurance on the behaviour of this substance is provided by means of the PBT assessment done using a weight of evidence (see section 2.3) where both EPWIIN data on components and a read-across substance fish BCF study have been considered and strongly suggest a lack of B potential for this substance can be concluded.
Key value for chemical safety assessment
Additional information
Based on the lack of exposure to the environment, no further testing on this endpoint is proposed or required. However, further reassurance on this property is provided by means of a weight of evidence assessment done for PBT assessment (see 2.3) where the experimental data from a structurally similar alkylphenol (EC#310-154-3) is also considered for this registration substance; both alkylphenols contain a range of similar alkyl chain lengths, the main difference being the degree of branching and metabolism is will proceed using similar pathways. A bioaccumulation study was conducted according to the OECD Guideline 305. Fish were exposed to two concentrations of tetrapropenylphenol in flow-through systems in stainless steel aquaria for a 27-day uptake period, which was followed by a 15-day depuration period. The test substance used was a mixture of radiolabelled tetrapropenylphenol (uniformly ringlabelled) and non-labelled commercial material. The BCF value of 823 was chosen as it was the worst case scenario based on the whole fish at a concentration of 1.1 µg/L. The results showed no indication of a bioaccumulation potential in aquatic organisms (BCF <2000) and the substance is not B or vB. This information can be read across to the registration substance with a high degree of confidence based on structural considerations, and supports the lack of a requirement for any further testing.
The EPWIN report completed for the components of this registration substance is attached to this ESR as supporting evidence, as is a copy of a summary of the read-across substance BCF data (also see ESR and PBT assessment).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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