Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
5th August 2013 (1 Day)
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
not specified
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction products of triethanolamine esters of polyphosphoric acids with alkyl derivatives of pyridine
EC Number:
939-981-3
IUPAC Name:
Reaction products of triethanolamine esters of polyphosphoric acids with alkyl derivatives of pyridine
Constituent 2
Chemical structure
Reference substance name:
Methanol
EC Number:
200-659-6
EC Name:
Methanol
Cas Number:
67-56-1
Molecular formula:
CH4O
IUPAC Name:
methanol
Test material form:
liquid
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: supplied by sponsor
- Expiration date of the lot/batch: N/A

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark
- Stability under storage conditions: Stable
- Stability under test conditions: Stable

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
2.4
pH:
>= 7.32 - <= 8.14
Remarks on result:
not measured/tested
Remarks:
Temperature not measured - room temperature

Applicant's summary and conclusion

Conclusions:
The mean CHARM weighted average log Pow for the test item was calculated to be 2.4. The range of log Pow for the seven peaks was from -0.21 to 3.57.
Executive summary:

The partition coefficient for the test item was found using the HPLC method according to OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

The mean CHARM weighted average log Pow for the test item was calculated to be 2.4. The range of log Pow for the seven peaks was from -0.21 to 3.57.