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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental dates: 05 April 2019 to 08 October 2020
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation affected the quality of the study. The substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling Point)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
Commission Regulation (EC) No 440/2008
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
issued 19/11/2018
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
Appearance: Extremely pale yellow liquid.
Storage Conditions: Refrigerated (2 to 8°C), dark, in an amber glass bottle.
Key result
Boiling pt.:
211 °C
Atm. press.:
101.3 kPa

Siwoloboff method
The results of duplicate boiling point determinations were as follows:
Barometric pressure: 1004 mbar
























 Boiling point (°C)
 Observed valuePressure corrected value
Run 1210.5210.5
Run 2210.0210.0

The observed and corrected values are presented to the nearest ± 0.5°C.
The duplicate determinations were within the estimated accuracy of the method (± 1°C).


DSC method
The confirmatory DSC traces showed a broad boiling endotherm with an extrapolated onset temperature of approximately 211°C (mean of 211°C and 212°C), consistent with the results from the Siwoloboff method. Testing was conducted at a barometric pressure of 1011 mbar.


A small exotherm was recorded at lower temperature, and is thought to be due to decomposition of a minor component; it is consistent with visual observations made during the Siwoloboff method, i.e. some evolution of gas below the boiling temperature and slight discoloration after boiling.

Executive summary:

The boiling point of the test substance was determined, under GLP, according to OECD103/EU A2 guidelines.
The boiling temperature was initially determined by the Siwoloboff method and confirmed by differential scanning calorimetry (DSC) to check the absence of decomposition. Two runs were performed for each test, and the measured values were corrected to standard atmospheric pressure.
The normal boiling point of the substance was determined as 211°C.

Description of key information

Experimental initial boiling point = 211°C (corrected to normal atmP). (OECD 103, capillary+DSC; GLP)

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
211 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EU method and under GLP, is available.


It is considered as a key study, and the result is retained as key data.