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EC number: 486-670-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- QUALITY ASSURANCE ATTESTATION, G.L.P. COMPLIANCE STATEMENT & GLP certificates included in the full report. The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. The substance is adequately characterised. Therefore full validation applies.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- test method B.4 of the directive 2004/73/EC
- Deviations:
- yes
- Remarks:
- Environmental parameters: A relative humidity of 19 % was registered instead of 30 % (minimal limit) as planned in the experimental protocol. A temperature of 24°C was registered instead of 23°C (maximal limit) as planned in the experimental protocol.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 6,8-dimethylnon-7-enal
- EC Number:
- 486-670-9
- Cas Number:
- 899810-84-5
- Molecular formula:
- C11H20O
- IUPAC Name:
- 6,8-dimethylnon-7-enal
- Test material form:
- other: liquid
- Details on test material:
- • Form : liquid
• Colour : colorless
• Batch n° : 862036
• Storage : room temperature
• Production date: September 2007 • Expiry date: September 2008
• Purity/Concentration: 97.79%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Three male albino New Zealand rabbits were supplied by the Elevage de Gérome (Quartier Labaste –
F40260 Linxe). They were kept during a minimal 5-day acclimatisation period. During the test, the
animals weighed between 2.54 kg and 3.33 kg. At the beginning of the test, the animals were 12 to 13-
week old.
Each animal was kept in an individual box installed in conventional air conditioned animal
husbanding; the environmental conditions were:
- temperature : between 18°C and 24°C
- relative humidity : between 19% and 70%
- lighting time: 12 hours daily
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- The test item was applied, as supplied, at a dose of 0.5 mL,
- Duration of treatment / exposure:
- 72 h
- Observation period:
- The skin reactions were appreciated 1 hour and then 24, 48 and 72 hours after removal of the patch.
- Number of animals:
- 3 males
- Details on study design:
- Approximately 24 hours before the test, the rabbits’ backs and flanks were shorn using electric
clippers equipped with a fine comb, so as to expose an area of skin about 6 cm2.
The test item was applied, as supplied, at a dose of 0.5 mL, on an undamaged skin area of one flank of
each animal, during 4 hours. The patch was secured in position with a strip of surgical adhesive tape.
After the removal of the patch, the treated area was rinsed with distilled water.
On the opposite flank an untreated area was served as the control.
Initially, a single animal was treated. After consideration of the cutaneous responses produced in the
first treated animal, two additional animals were treated.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- ca. 2
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- ca. 2
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- ca. 2
- Irritation parameter:
- erythema score
- Max. score:
- 2
- Remarks on result:
- other: Max. duration: 72 d; Max. value at end of observation period: CA 2 (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- ca. 2
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- ca. 1.7
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- ca. 1.7
- Irritation parameter:
- edema score
- Max. score:
- 2
- Remarks on result:
- other: Max. duration: 72 d; Max. value at end of observation period: CA 2 (related to all animals)
- Irritant / corrosive response data:
- It was noted, 1 hour after the test item application, on the treated area, a well defined erythema
associated with a slight oedema.
On the cutaneous structure, a dryness was noted on the treated area, from D3 in two animals and from
D6 in the last one. - Other effects:
- The oedematous reactions were totally reversible at D6 and the
erythematous reactions were totally reversible between D6 and D8.
The skin recovered a normal aspect between D9 and D10 in two animals but a
slight dryness was still registered the last day of the test (D14) in one animal.
La scheresse de la peau n'est pas rversible aprs 14 jours
pour un animal sur trois, elle est rversible pourles deux
autres entre 9 10 jours.
Any other information on results incl. tables
The individual and mean scores obtained during the study are given in the attached full report.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results obtained, under these experimental conditions, enable to conclude that the test item
according to the scales of interpretation retained:
- is irritant to skin (PSi = 3.7) according to the classification established in the Journal Officiel de la
République Française dated February 21st, 1982,
- and, needs to be classified “irritant to skin”, according to the EU criteria for classification,
packaging and labelling of dangerous substances and preparations. - Executive summary:
The test item was applied, as supplied, at the dose of 0.5 mL, under semiocclusive
dressing during 4 hours on an undamaged skin area of three rabbits. The experimental
protocol was established from the O.E.C.D. guideline n° 404 dated April 24th, 2002 and the test
method B.4 of the directive n° 2004/73/EC.
It was noted, 1 hour after the test item application, on the treated area, a well defined erythema
associated with a slight oedema. The oedematous reactions were totally reversible at D6 and the
erythematous reactions were totally reversible between D6 and D8.
On the cutaneous structure, a dryness was noted on the treated area, from D3 in two animals and from
D6 in the last one. The skin recovered a normal aspect between D9 and D10 in two animals but a
slight dryness was still registered the last day of the test (D14) in one animal.
The results obtained, under these experimental conditions, enable to conclude that the test item
needs to be classified R38 “irritant to skin”, according to the criteria for
classification, packaging and labelling of dangerous substances and preparations in compliance with
the E.E.C. Directives 67/548, 2001/59 and 99/45. The test item must be characterised by the symbol
“Xi” and the warning label “irritant”.
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