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Melting point / freezing point

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melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
08 November to 13 December 2007
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately identified, but details on composition are missing. Therefore validation applies with restrictions.
according to guideline
EU Method A.1 (Melting / Freezing Temperature)
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. QA statement)
effective 16 March 2007 (validity 18 months)
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
Storage conditions of test material: Stored at room temperature protected from direct sun light.
Key result
Melting / freezing pt.:
-121.1 °C

Table 4.2/1: Melting point – results

Test no.

Start temperature

Heating rate

Onset temperature


-180 °C

+10 °C/min

-121.0 °C


-150 °C

+10 °C/min

-121.2 °C


-150 °C

+10 °C/min

-121.2 °C

Mean ± S.D.

-121.1 °C ± 0.1 °C


Three successive tests were retained.

Mean onset for melting occurred at -121.1 °C ± 0.1 °C. The validity criteria were fulfilled: the standard deviation within the three replicate assessments did not exceed 0.5 °C. Therefore the average value is retained as final result.

Reference material: Ethanol. Nominal onset for boiling = 78.2 ± 0.5 °C. Measured onset = 78.3 °C

Executive summary:

The melting point of the test substance was determined under GLP according to EU Method A.1 by using differential scanning calorimetry (DSC).


Three main runs were performed, and the mean final temperature was retained.


The melting temperature of the test substance was determined to be -121.1 °C.

Description of key information

Experimental melting point (i.e. transition from solid to liquid) = -121.1°C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
-121.1 °C

Additional information

A reliable experimental study, conducted according to a recognized EC method and under GLP, is available.

Despite minor restrictions due to incomplete test item identification, it is considered as key study, and the result is retained as key data.