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EC number: 215-138-9
CAS number: 1305-78-8
(airborne fraction): total: 2.10 mg/g.
the original study report by DMT, a calculation of the mass median
diameter was not conducted. Since the deposited fractions were provided
for each of the cascade impactor stages, it was possible to fit a mono
modal lognormal distribution to the data by standard non-linear
regression procedure. As a result, the MMAD and GSD are calculable and
reported (MMAD = 18.26 µm, GSD = 2.97). As the cascade impactor already
takes aerodynamic characteristics of the particles into account, the
reported mass median diameter can be interpreted as the mass median aerodynamic
figure and the corresponding GSD were used as distribution parameters
for the MPPD model enabling an estimation of deposited dust fractions in
the human respiratory tract: These fractions were estimated as follows:
(ET): 55.7 %
(TB): 0.8 %
(PU): 1.1 %
Calcium oxide 0-2 mm:
Total Dustiness (airborne fraction): 100.01 mg/g (experimental results,
MMAD of airborne fraction: MMAD = 17.14 µm (distribution fitted to
cascade impactor data).
GSD of MMAD: GSD = 2.75 µm
Fractional deposition in human respiratory tract (MPPD model, based on
Head (ET): 59.2 %; Tracheobronchial (TB): 0.8 %; Pulmonary (PU): 1.1 %
Calcium oxide > 10 mm:
Total Dustiness (airborne fraction): 2.10 mg/g (experimental results,
MMAD of airborne fraction: MMAD = 18.26 µm (distribution fitted to
cascade impactor data).
GSD of MMAD: GSD = 2.97 µm
Head (ET): 55.7 %; Tracheobronchial (TB): 0.8 %; Pulmonary (PU): 1.1 %
For the evaluation of this endpoint, two
grades of calcium oxide (calcium oxide ≤ 2 mm and calcium oxide > 10 mm)
that were investigated according to national standard (DIN 55992
-1:2006, modified Heubach method). The respective results are used as
key information, supported by data from a guideline compliant study
The key studies were selected based on the
fact that these studies consider the airborne fraction of calcium oxide,
which is exposure-related and relevant to workplace conditions. The
other study, which is only used as supportive information, tested not
the airborne fraction of calcium oxide, but the total of the substance
fed in a cascade impactor. This is not exposure-related and not relevant
for workplace conditions.
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