Registration Dossier
Registration Dossier
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EC number: 240-032-4 | CAS number: 15894-70-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity test results with algae (Pseudokirchnerella subcapitata) resulted in 72-hr EC50 = 17mg/L, based on growth and 72-hr NOEC = 2.5mg/L, based on growth.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 17 mg/L
- EC10 or NOEC for freshwater algae:
- 2.5 mg/L
Additional information
A reliable (Klimisch 1) toxicity study with algae has been conducted with HMBDA and is included in this dossier.
Smyth et al. (1993) conducted a reliable (Klimisch 1) GLP compliant study according to OECD 201 methods.Selenastrum capricornutum(new name:Pseudokirchnerella subcapitata) were exposed to measured concentrations (0.59, 1.3, 2.5, 4.7, 9.1, 15, 20, 25 mg/l) of HMBDA for 72 hours in a static system.The 72-hr EC50, based on growth, was 17 mg/L. The 72-hr NOEC, based on growth, was 2.5 mg/L.
Adequate reliable measured data exists for toxicity of HMBDA to algae. The data point of highest concern for this endpoint has been identified in a reliable study which reports a measured 72 hr EC50 of 17 mg/L and 72 hr NOEC of 2.5 mg/L, based on growth, for toxicity to aquatic algae. Consequently these values will be taken as the toxicity in aquatic algae endpoint for HMBDA.
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