Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Several reliable (Klimisch 1 or 2) toxicity studies in fish, invertebrates, and algae have been conducted for HMBDA and are included in this dossier.  These Key studies are summarized below. There were no reliable long-term toxicity data for fish and invertebrates or toxicity data for microorganisms or aquatic plants.  However, a waiver is being applied for these endpoints. 

 

Adequate reliable measured data exists for short-term toxicity to fish for HMBDA and has been documented within this dossier. The most reliable study result for the test substance has been identified as a study (Holland et al. 1993) which reports an LC50 for short term toxicity in fish of >13 mg/L. Consequently this value will be taken as the short-term toxicity in fish endpoint for HMBDA.

 

There are no reliable (Klimisch 1 or 2) long-term toxicity studies with fish available with HMBDA. However, a waiver is applied for this endpoint on the basis of low solubility, minimal exposure to aquatic organisms and no adverse effects to fish are expected.

 

A reliable (Klimisch 1) short-term toxicity study with invertebrates has been conducted for HMBDA and is included in this dossier. The key study, Kent et al. (1993), provides a 48-hr LC50 of >21 mg/L forDaphnia magna. Consequently this value will be taken as the short-term toxicity in aquatic invertebrate’s endpoint for HMBDA.

 

There are no reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates available with HMBDA. However, a waiver is applied for this endpoint on the basis of low solubility and minimal exposure.

 

Adequate reliable measured data exists for toxicity of HMBDA to algae. The data point of highest concern for this endpoint has been identified in a reliable study which reports a measured 72 hr EC50 of 17 mg/L and 72 hr NOEC of 2.5 mg/L, based on growth, for toxicity to aquatic algae. Consequently these values will be taken as the toxicity in aquatic algae endpoint for HMBDA.

 

There are no reliable toxicity data for microoganisms with HMBDA. A waiver is applied for this endpoint on the basis of low to insoluble nature of the test substance and minimal exposure as the substance is an intermediate product and manufactured and utilized only at one location in the EU and handled under strictly controlled conditions.